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10.1016/j.immuni.2017.04.028 http://scihub22266oqcxt.onion/10.1016/j.immuni.2017.04.028 C5695239!5695239!28514674     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2017 ; 46 (5): 730-42 Nephropedia Template TP {{tp|p=28514674|t=2017. MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells |pdf=|usr=}}{{28514674}} gab.com Text MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28514674 #FOAvip Tissue-resident immune cells must balance survival in peripheral tissues with the capacity to respond rapidly upon infection or tissue damage, and in turn couple these responses with intrinsic metabolic control and conditions in the tissue microenvironment. The serine/threonine kinase mammalian/mechanistic target of rapamycin (mTOR) is a central integrator of extracellular and intracellular growth signals and cellular metabolism and plays important roles in both innate and adaptive immune responses. This review discusses the function of mTOR signaling in the differentiation and function of tissue-resident immune cells, with focus on the role of mTOR as a metabolic sensor and its impact on metabolic regulation in innate and adaptive immune cells. We also discuss the impact of metabolic constraints in tissues on immune homeostasis and disease, and how manipulating mTOR activity with drugs such as rapamycin can modulate immunity in these contexts. Twit Text FOAVip MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28514674 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28514674 #FOAvip English Wikipedia <ref>{{Cite pmid|28514674}}</ref> MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells #MMPMID28514674 Jones RG; Pearce EJ Immunity 2017[May]; 46 (5): 730-42 PMID28514674show ga Tissue-resident immune cells must balance survival in peripheral tissues with the capacity to respond rapidly upon infection or tissue damage, and in turn couple these responses with intrinsic metabolic control and conditions in the tissue microenvironment. The serine/threonine kinase mammalian/mechanistic target of rapamycin (mTOR) is a central integrator of extracellular and intracellular growth signals and cellular metabolism and plays important roles in both innate and adaptive immune responses. This review discusses the function of mTOR signaling in the differentiation and function of tissue-resident immune cells, with focus on the role of mTOR as a metabolic sensor and its impact on metabolic regulation in innate and adaptive immune cells. We also discuss the impact of metabolic constraints in tissues on immune homeostasis and disease, and how manipulating mTOR activity with drugs such as rapamycin can modulate immunity in these contexts. äMenTORing Immunity: mTOR Signaling in the Development and Function of (epmc).pdf DeepDyve Pubget Overpricing