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10.1101/gad.304972.117

http://scihub22266oqcxt.onion/10.1101/gad.304972.117
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C5695086!5695086!29021240
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suck abstract from ncbi


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pmid29021240      Genes+Dev 2017 ; 31 (18): 1847-57
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  • Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein #MMPMID29021240
  • Pourebrahim R; Zhang Y; Liu B; Gao R; Xiong S; Lin PP; McArthur MJ; Ostrowski MC; Lozano G
  • Genes Dev 2017[Sep]; 31 (18): 1847-57 PMID29021240show ga
  • Pourebrahim et al. developed a traceable somatic osteosarcoma mouse model that is initiated with either a single p53 mutation (p53R172H) or p53 loss in osteoblasts. They identified a cluster of Ets2-dependent small nucleolar RNAs (snoRNAs) that are highly up-regulated in p53 mutant tumors.
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