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10.1186/s12929-017-0394-0 http://scihub22266oqcxt.onion/10.1186/s12929-017-0394-0 C5694903!5694903 !29157234     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29157234 &cmd=llinks): Failed to open stream: HTTP request failed! 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Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease |pdf=|usr=}}{{29157234 }} gab.com Text Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease JO: J Biomed Sci http://www.kidney.de/pget.php?&tw=1&pmid=29157234 #FOAvip BACKGROUND: Zinc is a metal ion that is essential for growth and development, immunity, and metabolism, and therefore vital for life. Recent studies have highlighted zinc's dynamic role as an insulin mimetic and a cellular second messenger that controls many processes associated with insulin signaling and other downstream pathways that are amendable to glycemic control. MAIN BODY: Mechanisms that contribute to the decompartmentalization of zinc and dysfunctional zinc transporter mechanisms, including zinc signaling are associated with metabolic disease, including type 2 diabetes. The actions of the proteins involved in the uptake, storage, compartmentalization and distribution of zinc in cells is under intense investigation. Of these, emerging research has highlighted a role for several zinc transporters in the initiation of zinc signaling events in cells that lead to metabolic processes associated with maintaining insulin sensitivity and thus glycemic homeostasis. CONCLUSION: This raises the possibility that zinc transporters could provide novel utility to be targeted experimentally and in a clinical setting to treat patients with insulin resistance and thus introduce a new class of drug target with utility for diabetes pharmacotherapy. Twit Text FOAVip Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease ????J Biomed Sci http://www.kidney.de/pget.php?&tw=1&pmid=29157234 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29157234 #FOAvip English Wikipedia <ref>{{Cite pmid|29157234 }}</ref> Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease #MMPMID29157234 Norouzi S ; Adulcikas J ; Sohal SS ; Myers S J Biomed Sci 2017[Nov]; 24 (1 ): 87 PMID29157234 show ga BACKGROUND: Zinc is a metal ion that is essential for growth and development, immunity, and metabolism, and therefore vital for life. Recent studies have highlighted zinc's dynamic role as an insulin mimetic and a cellular second messenger that controls many processes associated with insulin signaling and other downstream pathways that are amendable to glycemic control. MAIN BODY: Mechanisms that contribute to the decompartmentalization of zinc and dysfunctional zinc transporter mechanisms, including zinc signaling are associated with metabolic disease, including type 2 diabetes. The actions of the proteins involved in the uptake, storage, compartmentalization and distribution of zinc in cells is under intense investigation. Of these, emerging research has highlighted a role for several zinc transporters in the initiation of zinc signaling events in cells that lead to metabolic processes associated with maintaining insulin sensitivity and thus glycemic homeostasis. CONCLUSION: This raises the possibility that zinc transporters could provide novel utility to be targeted experimentally and in a clinical setting to treat patients with insulin resistance and thus introduce a new class of drug target with utility for diabetes pharmacotherapy. |Animals [MESH] |Biological Transport [MESH] |Blood Glucose/*metabolism [MESH] |Carrier Proteins/*genetics/metabolism [MESH] |Diabetes Mellitus, Type 2/genetics/*therapy [MESH] |Homeostasis [MESH] |Humans [MESH] |Insulin Resistance/*genetics [MESH] |Metabolic Diseases/genetics/therapy [MESH] |Mice [MESH] |Rats [MESH]Zinc transporters and insulin resistance: therapeutic implications for(epmc).pdf DeepDyve Pubget Overpricing