Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29187821
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Pharmacol
2017 ; 8
(ä): 835
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Renoprotective Effect of Dipeptidyl Peptidase-4 Inhibitors in Patients with Type
2 Diabetes Mellitus
#MMPMID29187821
Esaki H
; Tachi T
; Goto C
; Sugita I
; Kanematsu Y
; Yoshida A
; Saito K
; Noguchi Y
; Ohno Y
; Aoyama S
; Yasuda M
; Mizui T
; Yamamura M
; Teramachi H
Front Pharmacol
2017[]; 8
(ä): 835
PMID29187821
show ga
Diabetic nephropathy is one of three major complications of diabetes mellitus,
often leading to chronic renal failure requiring dialysis. Recently developed
dipeptidyl peptidase-4 (DPP-4) inhibitors may exhibit renoprotective effects in
addition to antihyperglycemic effects. In this study, we retrospectively
investigated temporal changes in the renal function index of patients with type 2
diabetes mellitus (DM) and examined the influence of DPP-4 inhibitors on renal
function. Patients with type 2 DM (>18 years old) prescribed hypoglycemic agents
at Gifu Municipal Hospital for ?3 months between March 2010 and April 2014 were
included in the study. Renal function was evaluated as estimated the decline in
12-month glomerular filtration rate from the baseline in patients receiving and
not receiving DPP-4 inhibitors. Patient data from the DPP-4 inhibitor-treated
(501 patients, 58.6%) and untreated (354, 41.4%) groups were analyzed using
multiple logistic regression analysis, as well as Cox proportional-hazards
regression analysis (616, 55.6% and 491, 44.4%, for DPP-4 inhibitors-treated and
untreated groups). Multiple logistic regression analysis indicated that DPP-4
inhibitors significantly lowered the estimated glomerular filtration rate (eGFR)
decline [20% over 12 months; odds ratio (OR), 0.626; 95% confidence interval
[CI], 0.409-0.958; P = 0.031]. Similar results were obtained using Cox
proportional-hazards regression analysis (hazard ratio [HR], 0.707; 95% CI,
0.572-0.874; P = 0.001). These findings suggest that DPP-4 inhibitors suppress
the decrease of estimated glomerular filtration rate in patients with type 2 DM
and show a renoprotective effect.
free
free
free
