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10.1007/s13730-017-0269-y http://scihub22266oqcxt.onion/10.1007/s13730-017-0269-y C5694406!5694406 !28849361     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28849361 &cmd=llinks): Failed to open stream: HTTP request failed! 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Tubulointerstitial nephritis as adverse effect of programmed cell death 1 inhibitor, nivolumab, showed distinct histological findings |pdf=|usr=}}{{28849361 }} gab.com Text Tubulointerstitial nephritis as adverse effect of programmed cell death 1 inhibitor, nivolumab, showed distinct histological findings JO: CEN Case Rep http://www.kidney.de/pget.php?&tw=1&pmid=28849361 #FOAvip Immune-checkpoint inhibitor nivolumab (anti-PD-1 antibody) blocks T cell inhibition and stimulate immunologic response toward cancer cells. It was also revealed that PD-1/PD-L1 interaction crucially controls the effector differentiation of auto-reactive T cells to maintain self-tolerance. Therefore, potential autoimmunological side-effect can occur in any organ. Here, we report a case of 67-year-old Japanese male with lung adenocarcinoma treated with nivolumab who developed acute tubulointerstitial nephritis after the third infusion of nivolumab. Kidney biopsy showed distinct histological findings: Proliferation of CD38 positive and IgG positive plasma cells, and affluent infiltration of FoxP3(+) regulatory T cells. Herein, we do pathological discussion concerning acute tubulointerstitial nephritis occurred in this case based on these histological findings. Twit Text FOAVip Tubulointerstitial nephritis as adverse effect of programmed cell death 1 inhibitor, nivolumab, showed distinct histological findings ????CEN Case Rep http://www.kidney.de/pget.php?&tw=1&pmid=28849361 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28849361 #FOAvip English Wikipedia <ref>{{Cite pmid|28849361 }}</ref> Tubulointerstitial nephritis as adverse effect of programmed cell death 1 inhibitor, nivolumab, showed distinct histological findings #MMPMID28849361 Uchida A ; Watanabe M ; Nawata A ; Ikari Y ; Sasaki M ; Shigemoto K ; Hisano S ; Nakashima H CEN Case Rep 2017[Nov]; 6 (2 ): 169-174 PMID28849361 show ga Immune-checkpoint inhibitor nivolumab (anti-PD-1 antibody) blocks T cell inhibition and stimulate immunologic response toward cancer cells. It was also revealed that PD-1/PD-L1 interaction crucially controls the effector differentiation of auto-reactive T cells to maintain self-tolerance. Therefore, potential autoimmunological side-effect can occur in any organ. Here, we report a case of 67-year-old Japanese male with lung adenocarcinoma treated with nivolumab who developed acute tubulointerstitial nephritis after the third infusion of nivolumab. Kidney biopsy showed distinct histological findings: Proliferation of CD38 positive and IgG positive plasma cells, and affluent infiltration of FoxP3(+) regulatory T cells. Herein, we do pathological discussion concerning acute tubulointerstitial nephritis occurred in this case based on these histological findings. äTubulointerstitial nephritis as adverse effect of programmed cell deat(epmc).pdf DeepDyve Pubget Overpricing