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10.1038/s41598-017-16101-1

http://scihub22266oqcxt.onion/10.1038/s41598-017-16101-1
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suck abstract from ncbi


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pmid29150631
      Sci+Rep 2017 ; 7 (1 ): 15795
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  • Effect of Long-term Incretin-Based Therapies on Ischemic Heart Diseases in Patients with Type 2 Diabetes Mellitus: A Network Meta-analysis #MMPMID29150631
  • Chou CY ; Chang YT ; Yang JL ; Wang JY ; Lee TE ; Wang RY ; Hung CC
  • Sci Rep 2017[Nov]; 7 (1 ): 15795 PMID29150631 show ga
  • Patients with type 2 diabetes mellitus (T2DM) experience many cardiovascular complications. Several studies have demonstrated the cardioprotective effects of incretin-based therapies; however, there are few studies on the effects of long-term incretin-based therapies on cardiovascular events. Therefore, the present study conducted a systematic review and network meta-analysis to evaluate the effects of long-term incretin-based therapies on ischaemic diseases. We searched PubMed, CENTRAL, and Clinicaltrial.gov to retrieve randomised control trials reported until December 2016 and enrolled only RCTs with more than a 1-year follow-up. The network meta-analysis was performed using R Software with a GeMTC package. A total of 40 trials were included. Dipeptidyl peptidase 4 inhibitors and glucagon-like peptide-1 agonists were associated with a lower risk of myocardial infarction (MI) than were sulfonylureas (odds ratio [95% credible interval] 0.41 [0.24-0.71] and 0.48 [0.27-0.91], respectively). These results suggested that patients with T2DM receiving long-term incretin-based therapies have a lower risk of MI than do those receiving sulfonylurea-based therapy. These findings highlight the risks of cardiovascular events in patients who receive long-term incretin-based therapies, and may provide evidence for the selection of antidiabetic therapy in the future.
  • |Aged [MESH]
  • |Diabetes Mellitus, Type 2/*complications/*drug therapy [MESH]
  • |Dipeptidyl-Peptidase IV Inhibitors/pharmacology/therapeutic use [MESH]
  • |Female [MESH]
  • |Glucagon-Like Peptide 1/agonists/metabolism [MESH]
  • |Humans [MESH]
  • |Hypoglycemic Agents/pharmacology/therapeutic use [MESH]
  • |Incretins/*therapeutic use [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Myocardial Ischemia/*complications/*drug therapy [MESH]
  • |Publication Bias [MESH]
  • |Risk Factors [MESH]


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