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2017 ; 7
(1
): 15795
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Effect of Long-term Incretin-Based Therapies on Ischemic Heart Diseases in
Patients with Type 2 Diabetes Mellitus: A Network Meta-analysis
#MMPMID29150631
Chou CY
; Chang YT
; Yang JL
; Wang JY
; Lee TE
; Wang RY
; Hung CC
Sci Rep
2017[Nov]; 7
(1
): 15795
PMID29150631
show ga
Patients with type 2 diabetes mellitus (T2DM) experience many cardiovascular
complications. Several studies have demonstrated the cardioprotective effects of
incretin-based therapies; however, there are few studies on the effects of
long-term incretin-based therapies on cardiovascular events. Therefore, the
present study conducted a systematic review and network meta-analysis to evaluate
the effects of long-term incretin-based therapies on ischaemic diseases. We
searched PubMed, CENTRAL, and Clinicaltrial.gov to retrieve randomised control
trials reported until December 2016 and enrolled only RCTs with more than a
1-year follow-up. The network meta-analysis was performed using R Software with a
GeMTC package. A total of 40 trials were included. Dipeptidyl peptidase 4
inhibitors and glucagon-like peptide-1 agonists were associated with a lower risk
of myocardial infarction (MI) than were sulfonylureas (odds ratio [95% credible
interval] 0.41 [0.24-0.71] and 0.48 [0.27-0.91], respectively). These results
suggested that patients with T2DM receiving long-term incretin-based therapies
have a lower risk of MI than do those receiving sulfonylurea-based therapy. These
findings highlight the risks of cardiovascular events in patients who receive
long-term incretin-based therapies, and may provide evidence for the selection of
antidiabetic therapy in the future.
|Aged
[MESH]
|Diabetes Mellitus, Type 2/*complications/*drug therapy
[MESH]
|Dipeptidyl-Peptidase IV Inhibitors/pharmacology/therapeutic use
[MESH]