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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Oral+Investig
2017 ; 21
(9
): 2733-2740
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gab.com Text
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English Wikipedia
The caries preventive effect of 1-year use of low-dose xylitol chewing gum A
randomized placebo-controlled clinical trial in high-caries-risk adults
#MMPMID28303470
Cocco F
; Carta G
; Cagetti MG
; Strohmenger L
; Lingström P
; Campus G
Clin Oral Investig
2017[Dec]; 21
(9
): 2733-2740
PMID28303470
show ga
OBJECTIVES: The caries preventive effect of long-term use (1 year) of low-dosage
(2.5 g/die) of xylitol chewing gum in a high-caries-risk adult population was
evaluated. MATERIALS AND METHODS: In this randomized clinical trial, 179
high-caries-risk adults were assigned to two experimental groups, xylitol and
polyols. Caries status, salivary mutans streptococci (MS), and plaque pH were
re-evaluated after 2 years from baseline in 66 xylitol and 64 polyol subjects.
Outcomes (the net caries increment for initial, moderate, and extensive caries
lesions and for the caries experience) were evaluated using the nonparametric
Mann-Whitney U test. RESULTS: The total caries experience increment was
1.25 ± 1.26 in the xylitol group and 1.80 ± 2.33 in the polyol group (p = 0.01).
Subjects treated with xylitol chewing gums had a reduction of risk rate at tooth
level of 23% with respect to those treated with polyols with a number needed to
treat of 55 teeth. The area under the curve at pH 5.7 was statistically
significantly lower (p = 0.02) during the experimental period in the xylitol
group. A decrease of the concentration of salivary MS was noted in the xylitol
group (p < 0.01). CONCLUSIONS: Subjects using the low-dose xylitol chewing gum
showed a significantly lower increment of initial and extensive caries lesions
and overall a lower increment of caries experience. CLINICAL RELEVANCE: One-year
use of chewing gums provides an effective means for the prevention of caries
disease. TRIAL REGISTRATION NUMBER: NCT02310308.
|*Chewing Gum
[MESH]
|Adult
[MESH]
|Dental Caries/epidemiology/*prevention & control
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Hydrogen-Ion Concentration
[MESH]
|Incidence
[MESH]
|Italy/epidemiology
[MESH]
|Male
[MESH]
|Middle Aged
[MESH]
|Saliva/microbiology
[MESH]
|Sugar Alcohols/administration & dosage/therapeutic use
[MESH]
|Sweetening Agents/administration & dosage/*therapeutic use
[MESH]