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10.1038/s41467-017-01571-8 http://scihub22266oqcxt.onion/10.1038/s41467-017-01571-8 C5693957!5693957 !29150604     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29150604 &cmd=llinks): Failed to open stream: HTTP request failed! 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Transcriptional signature of human pro-inflammatory T(H)17 cells identifies reduced IL10 gene expression in multiple sclerosis |pdf=|usr=}}{{29150604 }} gab.com Text Transcriptional signature of human pro-inflammatory T(H)17 cells identifies reduced IL10 gene expression in multiple sclerosis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29150604 #FOAvip We have previously reported the molecular signature of murine pathogenic T(H)17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-?(+)IL-17(+) (T(H)1/17) and IFN-?(-)IL-17(+) (T(H)17) CD4(+) T cells display distinct transcriptional profiles in high-throughput transcription analyses. Compared to T(H)17 cells, T(H)1/17 cells have gene signatures with marked similarity to mouse pathogenic T(H)17 cells. Assessing 15 representative signature genes in patients with multiple sclerosis, we find that T(H)1/17 cells have elevated expression of CXCR3 and reduced expression of IFNG, CCL3, CLL4, GZMB, and IL10 compared to healthy controls. Moreover, higher expression of IL10 in T(H)17 cells is found in clinically stable vs. active patients. Our results define the molecular signature of human pro-inflammatory T(H)17 cells, which can be used to both identify pathogenic T(H)17 cells and to measure the effect of treatment on T(H)17 cells in human autoimmune diseases. Twit Text FOAVip Transcriptional signature of human pro-inflammatory T(H)17 cells identifies reduced IL10 gene expression in multiple sclerosis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29150604 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29150604 #FOAvip English Wikipedia <ref>{{Cite pmid|29150604 }}</ref> Transcriptional signature of human pro-inflammatory T(H)17 cells identifies reduced IL10 gene expression in multiple sclerosis #MMPMID29150604 Hu D ; Notarbartolo S ; Croonenborghs T ; Patel B ; Cialic R ; Yang TH ; Aschenbrenner D ; Andersson KM ; Gattorno M ; Pham M ; Kivisakk P ; Pierre IV ; Lee Y ; Kiani K ; Bokarewa M ; Tjon E ; Pochet N ; Sallusto F ; Kuchroo VK ; Weiner HL Nat Commun 2017[Nov]; 8 (1 ): 1600 PMID29150604 show ga We have previously reported the molecular signature of murine pathogenic T(H)17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-?(+)IL-17(+) (T(H)1/17) and IFN-?(-)IL-17(+) (T(H)17) CD4(+) T cells display distinct transcriptional profiles in high-throughput transcription analyses. Compared to T(H)17 cells, T(H)1/17 cells have gene signatures with marked similarity to mouse pathogenic T(H)17 cells. Assessing 15 representative signature genes in patients with multiple sclerosis, we find that T(H)1/17 cells have elevated expression of CXCR3 and reduced expression of IFNG, CCL3, CLL4, GZMB, and IL10 compared to healthy controls. Moreover, higher expression of IL10 in T(H)17 cells is found in clinically stable vs. active patients. Our results define the molecular signature of human pro-inflammatory T(H)17 cells, which can be used to both identify pathogenic T(H)17 cells and to measure the effect of treatment on T(H)17 cells in human autoimmune diseases. |*Gene Expression Profiling [MESH] |Adult [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Female [MESH] |Humans [MESH] |Interferon-gamma/genetics/metabolism [MESH] |Interleukin-10/*genetics/metabolism [MESH] |Male [MESH] |Mice [MESH] |Middle Aged [MESH] |Multiple Sclerosis/*genetics/metabolism [MESH] |Th1 Cells/metabolism [MESH]Transcriptional signature of human pro-inflammatory T(H)17 cells ident(epmc).pdf DeepDyve Pubget Overpricing