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10.3389/fimmu.2017.01576

http://scihub22266oqcxt.onion/10.3389/fimmu.2017.01576
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C5693857!5693857!29181011
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suck abstract from ncbi


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pmid29181011      Front+Immunol 2017 ; 8 (ä): ä
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  • From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of Tolerance #MMPMID29181011
  • Scott DW
  • Front Immunol 2017[]; 8 (ä): ä PMID29181011show ga
  • Recent efforts have concentrated on approaches to expand and ?specify? human regulatory T cells (Tregs) and to apply them to modulate adverse immune responses in autoimmunity and hemophilia. We have used retroviral transduction of specific T-cell receptor, single chain Fv, or antigen domains in Tregs to achieve this goal. Each of these approaches have advantages and disadvantages. Results with these engineered T cells and evolution of the research developments and paths that led to the development of specific regulatory approaches for tolerance are summarized.
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