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10.1021/acssynbio.7b00077 http://scihub22266oqcxt.onion/10.1021/acssynbio.7b00077 C5693606!5693606!28763188     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Synth+Biol 2017 ; 6 (11): 2056-66 Nephropedia Template TP {{tp|p=28763188|t=2017. A tug-of-war mechanism for pattern formation in a genetic network |pdf=|usr=}}{{28763188}} gab.com Text A tug-of-war mechanism for pattern formation in a genetic network JO: ACS Synth Biol http://www.kidney.de/pget.php?&tw=1&pmid=28763188 #FOAvip Synthesizing spatial patterns with genetic networks is an ongoing challenge in synthetic biology. A successful demonstration of pattern formation would imply a better understanding of systems in the natural world and advance applications in synthetic biology. In developmental systems, transient patterning may suffice in order to imprint instructions for long-term development. In this paper we show that transient but persistent patterns can emerge from a realizable synthetic gene network based on a toggle switch. We show that a bistable system incorporating diffusible molecules can generate patterns that resemble Turing patterns but are distinctly different in the underlying mechanism: diffusion of mutually inhibiting molecules creates a prolonged ?tug-of-war? between patches of cells at opposing bistable states. The patterns are transient but longer wavelength patterns persist for extended periods of time. Analysis of a representative small scale model implies the eigenvalues of the persistent modes are just above the threshold of stability. The results are verified through simulation of biologically relevant models. Twit Text FOAVip A tug-of-war mechanism for pattern formation in a genetic network ????ACS Synth Biol http://www.kidney.de/pget.php?&tw=1&pmid=28763188 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28763188 #FOAvip English Wikipedia <ref>{{Cite pmid|28763188}}</ref> A tug-of-war mechanism for pattern formation in a genetic network #MMPMID28763188 Gomez MM; Arcak M ACS Synth Biol 2017[Nov]; 6 (11): 2056-66 PMID28763188show ga Synthesizing spatial patterns with genetic networks is an ongoing challenge in synthetic biology. A successful demonstration of pattern formation would imply a better understanding of systems in the natural world and advance applications in synthetic biology. In developmental systems, transient patterning may suffice in order to imprint instructions for long-term development. In this paper we show that transient but persistent patterns can emerge from a realizable synthetic gene network based on a toggle switch. We show that a bistable system incorporating diffusible molecules can generate patterns that resemble Turing patterns but are distinctly different in the underlying mechanism: diffusion of mutually inhibiting molecules creates a prolonged ?tug-of-war? between patches of cells at opposing bistable states. The patterns are transient but longer wavelength patterns persist for extended periods of time. Analysis of a representative small scale model implies the eigenvalues of the persistent modes are just above the threshold of stability. The results are verified through simulation of biologically relevant models. äA tug-of-war mechanism for pattern formation in a genetic network (epmc).pdf DeepDyve Pubget Overpricing