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10.1186/s40834-016-0022-5 http://scihub22266oqcxt.onion/10.1186/s40834-016-0022-5 C5693520!5693520!29201401     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Contracept+Reprod+Med 2016 ; 1 (ä): ä Nephropedia Template TP {{tp|p=29201401|t=2016. Identification and potential role of telocytes in human uterine leiomyoma |pdf=|usr=}}{{29201401}} gab.com Text Identification and potential role of telocytes in human uterine leiomyoma JO: Contracept Reprod Med http://www.kidney.de/pget.php?&tw=1&pmid=29201401 #FOAvip Background: Telocytes are specialized interstitial tissue cell type. Our aim is to characterize telocytes in human uterine leiomyoma (ULM) and its adjacent myometrium (Myo-F) as well as normal myometrium (Myo-N). Methods: ULMs and Myo-F tissues were taken from hysterectomy specimens done to treat symptomatic uterine fibroids (N?=?20). Myo-N is isolated from hysterectomies done on ULM- free uteri for other benign indications (N?=?15).Telocytes were detected using immunohistochemistry to detect c-Kit (CD-117), as a surface marker expressed on telocytes, and electron microscopic examination to identify telocytes characteristic ultrastructure. Cellular count and electron microscopic features of telocytes in each of the studied tissues were compared. Results: Telocytes could be detected in ULMs, Myo-F and Myo-N using c-KIT immunostaining. Electron microscopy confirmed the presence of telocytes in the three types of tissues identifying their characteristic features including small triangular or fusiform cell bodies with extensive cellular prolongations. ULM telocytes showed ultrastructural features suggestive of high cellular activities. Cell counts of ULM telocytes (3.35?±?0.39) were significantly higher (P value?=?0.00039) than that of Myo-F (1.39?±?0.13). Myo-N (2.6?±?0.36) contained higher telocyte numbers than Myo-F (1.39?±?0.13), but the difference did not reach statistical significance (P value?=?0.19). Conclusions: Telocytes are detected in higher numbers and activity in ULMs than Myo-F or Myo-N. In ULMs, telocytes can work as a hormonal sensors for stem cells, provide scaffold for newly formed myocytes, or control important downstream signaling pathways. Twit Text FOAVip Identification and potential role of telocytes in human uterine leiomyoma ????Contracept Reprod Med http://www.kidney.de/pget.php?&tw=1&pmid=29201401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29201401 #FOAvip English Wikipedia <ref>{{Cite pmid|29201401}}</ref> Identification and potential role of telocytes in human uterine leiomyoma #MMPMID29201401 Othman ER; Elgamal DA; Refaiy AM; Abdelaal II; Abdel-Mola AF; Al-Hendy A Contracept Reprod Med 2016[]; 1 (ä): ä PMID29201401show ga Background: Telocytes are specialized interstitial tissue cell type. Our aim is to characterize telocytes in human uterine leiomyoma (ULM) and its adjacent myometrium (Myo-F) as well as normal myometrium (Myo-N). Methods: ULMs and Myo-F tissues were taken from hysterectomy specimens done to treat symptomatic uterine fibroids (N?=?20). Myo-N is isolated from hysterectomies done on ULM- free uteri for other benign indications (N?=?15).Telocytes were detected using immunohistochemistry to detect c-Kit (CD-117), as a surface marker expressed on telocytes, and electron microscopic examination to identify telocytes characteristic ultrastructure. Cellular count and electron microscopic features of telocytes in each of the studied tissues were compared. Results: Telocytes could be detected in ULMs, Myo-F and Myo-N using c-KIT immunostaining. Electron microscopy confirmed the presence of telocytes in the three types of tissues identifying their characteristic features including small triangular or fusiform cell bodies with extensive cellular prolongations. ULM telocytes showed ultrastructural features suggestive of high cellular activities. Cell counts of ULM telocytes (3.35?±?0.39) were significantly higher (P value?=?0.00039) than that of Myo-F (1.39?±?0.13). Myo-N (2.6?±?0.36) contained higher telocyte numbers than Myo-F (1.39?±?0.13), but the difference did not reach statistical significance (P value?=?0.19). Conclusions: Telocytes are detected in higher numbers and activity in ULMs than Myo-F or Myo-N. In ULMs, telocytes can work as a hormonal sensors for stem cells, provide scaffold for newly formed myocytes, or control important downstream signaling pathways. äIdentification and potential role of telocytes in human uterine leiomy(epmc).pdf DeepDyve Pubget Overpricing