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10.1016/j.bbamcr.2016.10.006 http://scihub22266oqcxt.onion/10.1016/j.bbamcr.2016.10.006 C5693326!5693326!27741412     free     free     free       Biochim+Biophys+Acta 2017 ; 1864 (1): 51-61 Nephropedia Template TP {{tp|p=27741412|t=2017. Pannexin1 as mediator of inflammation and cell death |pdf=|usr=}}{{27741412}} gab.com Text Pannexin1 as mediator of inflammation and cell death JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=27741412 #FOAvip Pannexins form channels at the plasma membrane surface that establish a pathway for communication between the cytosol of individual cells and their extracellular environment. By doing so, pannexin signaling dictates several physiological functions, but equally underlies a number of pathological processes. Indeed, pannexin channels drive inflammation by assisting in the activation of inflammasomes, the release of pro-inflammatory cytokines, and the activation and migration of leukocytes. Furthermore, these cellular pores facilitate cell death, including apoptosis, pyroptosis and autophagy. The present paper reviews the roles of pannexin channels in inflammation and cell death. In a first part, a state-of-the-art overview of pannexin channel structure, regulation and function is provided. In a second part, the mechanisms behind their involvement in inflammation and cell death are discussed. Twit Text FOAVip Pannexin1 as mediator of inflammation and cell death ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=27741412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27741412 #FOAvip English Wikipedia <ref>{{Cite pmid|27741412}}</ref> Pannexin1 as mediator of inflammation and cell death #MMPMID27741412 Yanguas Crespo S; Willebrords J; Johnstone SR; Maes M; Decrock E; De Bock M; Leybaert L; Cogliati B; Vinken M Biochim Biophys Acta 2017[Jan]; 1864 (1): 51-61 PMID27741412show ga Pannexins form channels at the plasma membrane surface that establish a pathway for communication between the cytosol of individual cells and their extracellular environment. By doing so, pannexin signaling dictates several physiological functions, but equally underlies a number of pathological processes. Indeed, pannexin channels drive inflammation by assisting in the activation of inflammasomes, the release of pro-inflammatory cytokines, and the activation and migration of leukocytes. Furthermore, these cellular pores facilitate cell death, including apoptosis, pyroptosis and autophagy. The present paper reviews the roles of pannexin channels in inflammation and cell death. In a first part, a state-of-the-art overview of pannexin channel structure, regulation and function is provided. In a second part, the mechanisms behind their involvement in inflammation and cell death are discussed. äPannexin1 as mediator of inflammation and cell death (epmc).pdf DeepDyve Pubget Overpricing