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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (45): E9685-91 Nephropedia Template TP
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Thin myelin sheaths as the hallmark of remyelination persist over time and preserve axon function #MMPMID29078396
Duncan ID; Marik RL; Broman AT; Heidari M
Proc Natl Acad Sci U S A 2017[Nov]; 114 (45): E9685-91 PMID29078396show ga
The hallmark of remyelination in the CNS has been proposed to be the presence of thin myelin sheaths. This has been demonstrated in multiple experimental models and in multiple sclerosis. It is the only surrogate marker of remyelination, and therefore a crucial fingerprint of myelin repair. However, this has been challenged recently in separate studies, in which, by implication, the degree or presence of remyelinated axons has been underestimated. In this article, we provide evidence from two different models that thin myelin sheaths and short internodes persist almost indefinitely. Future attempts to promote myelin repair in models of multiple sclerosis will be crucially dependent on a definitive marker of repair. We propose that the thin myelin sheath remains the gold standard.