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10.1016/j.ccell.2017.10.003 http://scihub22266oqcxt.onion/10.1016/j.ccell.2017.10.003 C5691891!5691891!29136509     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Cell 2017 ; 32 (5): 669-683.e5 Nephropedia Template TP {{tp|p=29136509|t=2017. An HIF-1?/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression |pdf=|usr=}}{{29136509}} gab.com Text An HIF-1 /VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=29136509 #FOAvip Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1?, but not HIF-2?, was essential for the effector state in CD8+ T cells. Furthermore, loss of HIF-1? in CD8+ T cells reduced tumor infiltration and tumor cell killing, and altered tumor vascularization. Deletion of VEGF-A, an HIF target gene, in CD8+ T cells accelerated tumorigenesis while also altering vascularization. Analyses of human breast cancer showed inverse correlations between VEGF-A expression and CD8+ T cell infiltration, and a link between T cell infiltration and vascularization. These data demonstrate that the HIF-1?/VEGF-A axis is an essential aspect of tumor immunity. Twit Text FOAVip An HIF-1 /VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=29136509 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29136509 #FOAvip English Wikipedia <ref>{{Cite pmid|29136509}}</ref> An HIF-1?/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression #MMPMID29136509 Palazon A; Tyrakis PA; Macias D; Veliça P; Rundqvist H; Fitzpatrick S; Vojnovic N; Phan AT; Loman N; Hedenfalk I; Hatschek T; Lövrot J; Foukakis T; Goldrath AW; Bergh J; Johnson RS Cancer Cell 2017[Nov]; 32 (5): 669-683.e5 PMID29136509show ga Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1?, but not HIF-2?, was essential for the effector state in CD8+ T cells. Furthermore, loss of HIF-1? in CD8+ T cells reduced tumor infiltration and tumor cell killing, and altered tumor vascularization. Deletion of VEGF-A, an HIF target gene, in CD8+ T cells accelerated tumorigenesis while also altering vascularization. Analyses of human breast cancer showed inverse correlations between VEGF-A expression and CD8+ T cell infiltration, and a link between T cell infiltration and vascularization. These data demonstrate that the HIF-1?/VEGF-A axis is an essential aspect of tumor immunity. äAn HIF-1?/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression(epmc).pdf DeepDyve Pubget Overpricing