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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Neuroinflammation
2017 ; 14
(1
): 224
Nephropedia Template TP
gab.com Text
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Anti-NF155 chronic inflammatory demyelinating polyradiculoneuropathy strongly
associates to HLA-DRB15
#MMPMID29145880
Martinez-Martinez L
; Lleixà MC
; Boera-Carnicero G
; Cortese A
; Devaux J
; Siles A
; Rajabally Y
; Martinez-Piñeiro A
; Carvajal A
; Pardo J
; Delmont E
; Attarian S
; Diaz-Manera J
; Callegari I
; Marchioni E
; Franciotta D
; Benedetti L
; Lauria G
; de la Calle Martin O
; Juárez C
; Illa I
; Querol L
J Neuroinflammation
2017[Nov]; 14
(1
): 224
PMID29145880
show ga
BACKGROUND: The aim of the research is to study the human leukocyte antigen (HLA)
class II allele frequencies in chronic inflammatory demyelinating
polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155)
antibodies. METHODS: Thirteen anti-NF155+ and 35 anti-NF155 negative
(anti-NF155neg) CIDP patients were included in a case-control study. The
frequencies of the DRB1 HLA allele were analyzed in all patients while DQ
frequencies were only studied in patients sharing the DRB1*15 allele. In silico
HLA-peptide binding and NF155 antigenicity, predictions were performed to analyze
overlap between presented peptides and antigenic regions. RESULTS: DRB1*15
alleles (DRB1*15:01 and DRB1*15:02) were present in 10 out of 13 anti-NF155+ CIDP
patients and in only 5 out of 35 anti-NF155neg CIDP patients (77 vs 14%; OR?=?20,
CI?=?4.035 to 99.13). DRB1*15 alleles appeared also in significantly higher
proportions in anti-NF155+ CIDP than in normal population (77 vs 17%; OR?=?16.9,
CI?=?4.434 to 57.30). Seven anti-NF155+ CIDP patients (53%) and 5 anti-NF155neg
CIDP patients had the DRB1*15:01 allele (OR?=?7, p?=?0.009), while 3 anti-NF155+
CIDP patients and none of the anti-NF155neg CIDP patients had the DRB1*15:02
allele (OR?=?23.6, p?=?0.016). In silico analysis of the NF155 peptides binding
to DRB1*15 alleles showed significant overlap in the peptides presented by the
15:01 and 15:02 alleles, suggesting functional homology. CONCLUSIONS: DRB1*15
alleles are the first strong risk factor associated to a CIDP subset, providing
additional evidence that anti-NF155+ CIDP patients constitute a differentiated
disease within the CIDP syndrome.
|Adult
[MESH]
|Aged
[MESH]
|Autoantibodies/immunology
[MESH]
|Autoantigens/immunology
[MESH]
|Case-Control Studies
[MESH]
|Cell Adhesion Molecules/*immunology
[MESH]
|Female
[MESH]
|Gene Frequency
[MESH]
|Genetic Predisposition to Disease/*genetics
[MESH]
free
free
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