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10.1038/s41467-017-01231-x http://scihub22266oqcxt.onion/10.1038/s41467-017-01231-x C5691081!5691081!29146911     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29146911|t=2017. Cytokinesis requires localized ?-actin filament production by an actin isoform specific nucleator |pdf=|usr=}}{{29146911}} gab.com Text Cytokinesis requires localized -actin filament production by an actin isoform specific nucleator JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29146911 #FOAvip Cytokinesis is initiated by the localized assembly of the contractile ring, a dynamic actomyosin structure that generates a membrane furrow between the segregating chromosomal masses to divide a cell into two. Here we show that the stabilization and organization of the cytokinetic furrow is specifically dependent on localized ?-actin filament assembly at the site of cytokinesis. ?-actin filaments are assembled directly at the furrow by an anillin-dependent pathway that enhances RhoA-dependent activation of the formin DIAPH3, an actin nucleator. DIAPH3 specifically generates homopolymeric filaments of ?-actin in vitro. By employing enhancers and activators, cells can achieve acute spatio-temporal control over isoform-specific actin arrays that are required for distinct cellular functions. Twit Text FOAVip Cytokinesis requires localized -actin filament production by an actin isoform specific nucleator ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29146911 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29146911 #FOAvip English Wikipedia <ref>{{Cite pmid|29146911}}</ref> Cytokinesis requires localized ?-actin filament production by an actin isoform specific nucleator #MMPMID29146911 Chen A; Arora PD; McCulloch CA; Wilde A Nat Commun 2017[]; 8 (ä): ä PMID29146911show ga Cytokinesis is initiated by the localized assembly of the contractile ring, a dynamic actomyosin structure that generates a membrane furrow between the segregating chromosomal masses to divide a cell into two. Here we show that the stabilization and organization of the cytokinetic furrow is specifically dependent on localized ?-actin filament assembly at the site of cytokinesis. ?-actin filaments are assembled directly at the furrow by an anillin-dependent pathway that enhances RhoA-dependent activation of the formin DIAPH3, an actin nucleator. DIAPH3 specifically generates homopolymeric filaments of ?-actin in vitro. By employing enhancers and activators, cells can achieve acute spatio-temporal control over isoform-specific actin arrays that are required for distinct cellular functions. äCytokinesis requires localized ?-actin filament production by an actin(epmc).pdf DeepDyve Pubget Overpricing