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10.1038/s41467-017-01231-x http://scihub22266oqcxt.onion/10.1038/s41467-017-01231-x C5691081!5691081 !29146911     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29146911 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29146911 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 1530 Nephropedia Template TP {{tp|p=29146911 |t=2017. Cytokinesis requires localized ?-actin filament production by an actin isoform specific nucleator |pdf=|usr=}}{{29146911 }} gab.com Text Cytokinesis requires localized -actin filament production by an actin isoform specific nucleator JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29146911 #FOAvip Cytokinesis is initiated by the localized assembly of the contractile ring, a dynamic actomyosin structure that generates a membrane furrow between the segregating chromosomal masses to divide a cell into two. Here we show that the stabilization and organization of the cytokinetic furrow is specifically dependent on localized ?-actin filament assembly at the site of cytokinesis. ?-actin filaments are assembled directly at the furrow by an anillin-dependent pathway that enhances RhoA-dependent activation of the formin DIAPH3, an actin nucleator. DIAPH3 specifically generates homopolymeric filaments of ?-actin in vitro. By employing enhancers and activators, cells can achieve acute spatio-temporal control over isoform-specific actin arrays that are required for distinct cellular functions. Twit Text FOAVip Cytokinesis requires localized -actin filament production by an actin isoform specific nucleator ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29146911 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29146911 #FOAvip English Wikipedia <ref>{{Cite pmid|29146911 }}</ref> Cytokinesis requires localized ?-actin filament production by an actin isoform specific nucleator #MMPMID29146911 Chen A ; Arora PD ; McCulloch CA ; Wilde A Nat Commun 2017[Nov]; 8 (1 ): 1530 PMID29146911 show ga Cytokinesis is initiated by the localized assembly of the contractile ring, a dynamic actomyosin structure that generates a membrane furrow between the segregating chromosomal masses to divide a cell into two. Here we show that the stabilization and organization of the cytokinetic furrow is specifically dependent on localized ?-actin filament assembly at the site of cytokinesis. ?-actin filaments are assembled directly at the furrow by an anillin-dependent pathway that enhances RhoA-dependent activation of the formin DIAPH3, an actin nucleator. DIAPH3 specifically generates homopolymeric filaments of ?-actin in vitro. By employing enhancers and activators, cells can achieve acute spatio-temporal control over isoform-specific actin arrays that are required for distinct cellular functions. |Actin Cytoskeleton/*metabolism [MESH] |Actins/*metabolism [MESH] |Actomyosin/metabolism [MESH] |Adaptor Proteins, Signal Transducing/*metabolism [MESH] |Blood Platelets/physiology [MESH] |Cell Membrane/metabolism [MESH] |Cytokinesis/*physiology [MESH] |Formins [MESH] |HeLa Cells [MESH] |Humans [MESH] |Microfilament Proteins/genetics/*metabolism [MESH] |Microscopy, Fluorescence [MESH] |Protein Isoforms/metabolism [MESH] |RNA, Small Interfering/metabolism [MESH] |Recombinant Proteins/metabolism [MESH]Cytokinesis requires localized ?-actin filament production by an actin(epmc).pdf DeepDyve Pubget Overpricing