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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP
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Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses #MMPMID29147022
Cruz-Adalia A; Ramirez-Santiago G; Osuna-Pérez J; Torres-Torresano M; Zorita V; Martínez-Riaño A; Boccasavia V; Borroto A; Martínez del Hoyo G; González-Granado JM; Alarcón B; Sánchez-Madrid F; Veiga E
Nat Commun 2017[]; 8 (ä): ä PMID29147022show ga
Bacterial phagocytosis and antigen cross-presentation to activate CD8+ T cells are principal functions of professional antigen presenting cells. However, conventional CD4+ T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8+ T cells, which proliferate and become cytotoxic in response. CD4+ T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8+ T cells with low PD-1 expression. Moreover, transphagocytic CD4+ T cells induce protective anti-tumour immune responses by priming CD8+ T cells, highlighting the potential of CD4+ T cells as a tool for cancer immunotherapy.