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10.1038/s41467-017-01661-7 http://scihub22266oqcxt.onion/10.1038/s41467-017-01661-7 C5691066!5691066 !29147022     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29147022 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 1591 Nephropedia Template TP {{tp|p=29147022 |t=2017. Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses |pdf=|usr=}}{{29147022 }} gab.com Text Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29147022 #FOAvip Bacterial phagocytosis and antigen cross-presentation to activate CD8(+) T cells are principal functions of professional antigen presenting cells. However, conventional CD4(+) T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8(+) T cells, which proliferate and become cytotoxic in response. CD4(+) T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8(+) T cells with low PD-1 expression. Moreover, transphagocytic CD4(+) T cells induce protective anti-tumour immune responses by priming CD8(+) T cells, highlighting the potential of CD4(+) T cells as a tool for cancer immunotherapy. Twit Text FOAVip Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29147022 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29147022 #FOAvip English Wikipedia <ref>{{Cite pmid|29147022 }}</ref> Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses #MMPMID29147022 Cruz-Adalia A ; Ramirez-Santiago G ; Osuna-Pérez J ; Torres-Torresano M ; Zorita V ; Martínez-Riaño A ; Boccasavia V ; Borroto A ; Martínez Del Hoyo G ; González-Granado JM ; Alarcón B ; Sánchez-Madrid F ; Veiga E Nat Commun 2017[Nov]; 8 (1 ): 1591 PMID29147022 show ga Bacterial phagocytosis and antigen cross-presentation to activate CD8(+) T cells are principal functions of professional antigen presenting cells. However, conventional CD4(+) T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8(+) T cells, which proliferate and become cytotoxic in response. CD4(+) T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8(+) T cells with low PD-1 expression. Moreover, transphagocytic CD4(+) T cells induce protective anti-tumour immune responses by priming CD8(+) T cells, highlighting the potential of CD4(+) T cells as a tool for cancer immunotherapy. |Animals [MESH] |Antigen Presentation/*immunology [MESH] |Antigens, Bacterial/*immunology [MESH] |CD4-Positive T-Lymphocytes/*immunology [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Cells, Cultured [MESH] |Cross-Priming/immunology [MESH] |Cytotoxicity, Immunologic/immunology [MESH] |Immunologic Memory/immunology [MESH] |Immunological Synapses/immunology [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Phagocytosis/immunology [MESH]Conventional CD4(+) T cells present bacterial antigens to induce cytot(epmc).pdf DeepDyve Pubget Overpricing