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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2017 ; 96
(45
): e8379
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Optical coherence tomography angiography in patients with diabetic retinopathy
treated with anti-VEGF intravitreal injections: Case report
#MMPMID29137019
Michalska-Ma?ecka K
; Heinke Knudsen A
Medicine (Baltimore)
2017[Nov]; 96
(45
): e8379
PMID29137019
show ga
PURPOSE: To present optical coherence tomography angiography (OCTA) features in
patients with diabetic retinopathy (DR) at the baseline and in response to
treatment with anti-VEGF intravitreal injections. To investigate the role of OCTA
in management of patients with DR. METHODS: Retrospective case series showing
primary outcomes of 3 patients with DR and diabetic macular edema. Patients were
injected intravitreally a loading phase of 3 monthly 2.0?mg aflibercept, followed
by 2 injections bimonthly (5 injections in total). Before each injection OCTA was
performed using 3?mm?×?3?mm scans (Optovue, XR Avanti). The obtained scans of the
macula were analyzed and compared to the image at the baseline. Best-corrected
visual acuity (BCVA) was examined at the baseline and before each injection.
RESULTS: In the superficial plexus, a rarefaction of capillaries with capillary
dropout and nonperfusion areas were present in all eyes. The microaneurysms were
good to visualize in 3?mm?×?3?mm scans. In deep vascular network, evident
microvascular alterations around the small cystoid edema cells were to detect.
There were no differences in perfusion density level for the whole macular area
in 3?mm?×?3?mm scans shown in density maps between injections in all presented
cases. After a series of aflibercept intravitreal injections decreased cystic
changes were observed. Moreover in all presented cases, the decrease in central
retinal thickness that correlated clinically with improvement of visual acuity
(BCVA) was observed. All patients achieved a goal of well-controlled diabetes by
having a HbA1c level (<8.0%) before each injection. CONCLUSIONS: OCTA is a
dyeless, quick, and noninvasive method which allows to detect ischemic changes in
DR and might be a useful tool in observing the progress of the disease and the
response to anti-VEGF treatment in clinical practice.
|Aged
[MESH]
|Angiogenesis Inhibitors/administration & dosage/*therapeutic use
[MESH]