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10.3934/publichealth.2016.2.407

http://scihub22266oqcxt.onion/10.3934/publichealth.2016.2.407
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C5690364!5690364!29546172
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suck abstract from ncbi


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pmid29546172      AIMS+Public+Health 2016 ; 3 (2): 407-22
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  • Beneficial Role of Coffee and Caffeine in Neurodegenerative Diseases: A Minireview #MMPMID29546172
  • SC Y; Muralidhara
  • AIMS Public Health 2016[]; 3 (2): 407-22 PMID29546172show ga
  • Coffee is among the most widespread and healthiest beverages in the world. Coffee typically contains more caffeine than most other beverages, and is widely and frequently consumed. Thus, it contributes significantly to the overall caffeine consumption within the general population, particularly in adults. Controversies regarding its benefits and risks still exist as reliable evidence is becoming available supporting its health-promoting potential. Several lines of evidence have highlighted the beneficial effects towards several disease conditions including Type II diabetes, hepatitis C virus, hepatocellular carcinoma, nonalcoholic fatty liver disease and neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS). The health-promoting properties of coffee are largely attributed to its rich phytochemistry, including caffeine, chlorogenic acid, caffeic acid, and hydroxy hydroquinone. In this minireview, an attempt has been made to discuss the various evidences which are mainly derived from animal and cell models. Various mechanisms chiefly responsible for the beneficial effects of caffeine have also been briefly outlined. A short note on the undesirable effects of excessive coffee intakes is also presented.
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