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Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Stem+Cells+Transl+Med 2017 ; 6 (9): 1753-8 Nephropedia Template TP
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Stem Cell?Derived Extracellular Vesicles as a Novel Potential Therapeutic Tool for Tissue Repair #MMPMID28653443
Chen B; Li Q; Zhao B; Wang Y
Stem Cells Transl Med 2017[Sep]; 6 (9): 1753-8 PMID28653443show ga
Stem cells, with their therapeutic potential in tissue repair and regeneration, have been widely used in translational medicine. Recent evidence suggests that the beneficial effects are mediated largely by their paracrine actions rather than the engraftment and differentiation at the injured sites. Extracellular vesicles (EVs), actively released from cells, play important roles in cell?to?cell communication and display multiple functions in tissue regeneration. In the present report, we will briefly review the current knowledge related to the therapeutic potential of EVs, particularly stem cell or progenitor cell?derived ones for promoting tissue repair and regeneration, and focus on the restorative properties of exosomes/microvesicles in cutaneous wound healing, bone regeneration, hindlimb ischemia, and vascular injury repair. Stem Cells Translational Medicine2017;6:1753?1758