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10.18632/oncotarget.19626 http://scihub22266oqcxt.onion/10.18632/oncotarget.19626 C5689605!5689605 !29156715     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29156715 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (49 ): 85224-85233 Nephropedia Template TP {{tp|p=29156715 |t=2017. Connective tissue growth factor mediates TGF-?1-induced low-grade serous ovarian tumor cell apoptosis |pdf=|usr=}}{{29156715 }} gab.com Text Connective tissue growth factor mediates TGF- 1-induced low-grade serous ovarian tumor cell apoptosis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29156715 #FOAvip Ovarian low-grade serous carcinoma (LGSC) is a rare disease and is now considered to be a distinct entity from high-grade serous carcinoma (HGSC), which is the most common and malignant form of epithelial ovarian cancer. Connective tissue growth factor (CTGF) is a secreted matricellular protein that has been shown to modulate many biological functions by interacting with multiple molecules in the microenvironment. Increasing evidence indicates that aberrant expression of CTGF is associated with cancer development and progression. Transforming growth factor-?1 (TGF-?1) is a well-known molecule that can strongly up-regulate CTGF expression in different types of normal and cancer cells. Our previous study demonstrated that TGF-?1 induces apoptosis of LGSC cells. However, the effect of TGF-?1 on CTGF expression in LGSC needs to be defined. In addition, whether CTGF mediates TGF-?1-induced LGSC cell apoptosis remains unknown. In the present study, we show that TGF-?1 treatment up-regulates CTGF expression by activating SMAD3 signaling in two human LGSC cell lines. Additionally, siRNA-mediated CTGF knockdown attenuates TGF-?1-induced cell apoptosis. Moreover, our results show that the inhibitory effect of the CTGF knockdown on TGF-?1-induced cell apoptosis is mediated by down-regulating SMAD3 expression. This study demonstrates an important role for CTGF in mediating the pro-apoptotic effects of TGF-?1 on LGCS. Twit Text FOAVip Connective tissue growth factor mediates TGF- 1-induced low-grade serous ovarian tumor cell apoptosis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29156715 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29156715 #FOAvip English Wikipedia <ref>{{Cite pmid|29156715 }}</ref> Connective tissue growth factor mediates TGF-?1-induced low-grade serous ovarian tumor cell apoptosis #MMPMID29156715 Cheng JC ; Chang HM ; Leung PCK Oncotarget 2017[Oct]; 8 (49 ): 85224-85233 PMID29156715 show ga Ovarian low-grade serous carcinoma (LGSC) is a rare disease and is now considered to be a distinct entity from high-grade serous carcinoma (HGSC), which is the most common and malignant form of epithelial ovarian cancer. Connective tissue growth factor (CTGF) is a secreted matricellular protein that has been shown to modulate many biological functions by interacting with multiple molecules in the microenvironment. Increasing evidence indicates that aberrant expression of CTGF is associated with cancer development and progression. Transforming growth factor-?1 (TGF-?1) is a well-known molecule that can strongly up-regulate CTGF expression in different types of normal and cancer cells. Our previous study demonstrated that TGF-?1 induces apoptosis of LGSC cells. However, the effect of TGF-?1 on CTGF expression in LGSC needs to be defined. In addition, whether CTGF mediates TGF-?1-induced LGSC cell apoptosis remains unknown. In the present study, we show that TGF-?1 treatment up-regulates CTGF expression by activating SMAD3 signaling in two human LGSC cell lines. Additionally, siRNA-mediated CTGF knockdown attenuates TGF-?1-induced cell apoptosis. Moreover, our results show that the inhibitory effect of the CTGF knockdown on TGF-?1-induced cell apoptosis is mediated by down-regulating SMAD3 expression. This study demonstrates an important role for CTGF in mediating the pro-apoptotic effects of TGF-?1 on LGCS. äConnective tissue growth factor mediates TGF-?1-induced low-grade sero(epmc).pdf DeepDyve Pubget Overpricing