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10.18632/oncotarget.19490 http://scihub22266oqcxt.onion/10.18632/oncotarget.19490 C5689599!5689599 !29156709     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29156709 &cmd=llinks): Failed to open stream: HTTP request failed! 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Using molecular functional networks to manifest connections between obesity and obesity-related diseases |pdf=|usr=}}{{29156709 }} gab.com Text Using molecular functional networks to manifest connections between obesity and obesity-related diseases JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29156709 #FOAvip Obesity is a primary risk factor for many diseases such as certain cancers. In this study, we have developed three algorithms including a random-walk based method OBNet, a shortest-path based method OBsp and a direct-overlap method OBoverlap, to reveal obesity-disease connections at protein-interaction subnetworks corresponding to thousands of biological functions and pathways. Through literature mining, we also curated an obesity-associated disease list, by which we compared the methods. As a result, OBNet outperforms other two methods. OBNet can predict whether a disease is obesity-related based on its associated genes. Meanwhile, OBNet identifies extensive connections between obesity genes and genes associated with a few diseases at various functional modules and pathways. Using breast cancer and Type 2 diabetes as two examples, OBNet identifies meaningful genes that may play key roles in connecting obesity and the two diseases. For example, TGFB1 and VEGFA are inferred to be the top two key genes mediating obesity-breast cancer connection in modules associated with brain development. Finally, the top modules identified by OBNet in breast cancer significantly overlap with modules identified from TCGA breast cancer gene expression study, revealing the power of OBNet in identifying biological processes involved in the disease. Twit Text FOAVip Using molecular functional networks to manifest connections between obesity and obesity-related diseases ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29156709 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29156709 #FOAvip English Wikipedia <ref>{{Cite pmid|29156709 }}</ref> Using molecular functional networks to manifest connections between obesity and obesity-related diseases #MMPMID29156709 Yang J ; Qiu J ; Wang K ; Zhu L ; Fan J ; Zheng D ; Meng X ; Yang J ; Peng L ; Fu Y ; Zhang D ; Peng S ; Huang H ; Zhang Y Oncotarget 2017[Oct]; 8 (49 ): 85136-85149 PMID29156709 show ga Obesity is a primary risk factor for many diseases such as certain cancers. In this study, we have developed three algorithms including a random-walk based method OBNet, a shortest-path based method OBsp and a direct-overlap method OBoverlap, to reveal obesity-disease connections at protein-interaction subnetworks corresponding to thousands of biological functions and pathways. Through literature mining, we also curated an obesity-associated disease list, by which we compared the methods. As a result, OBNet outperforms other two methods. OBNet can predict whether a disease is obesity-related based on its associated genes. Meanwhile, OBNet identifies extensive connections between obesity genes and genes associated with a few diseases at various functional modules and pathways. Using breast cancer and Type 2 diabetes as two examples, OBNet identifies meaningful genes that may play key roles in connecting obesity and the two diseases. For example, TGFB1 and VEGFA are inferred to be the top two key genes mediating obesity-breast cancer connection in modules associated with brain development. Finally, the top modules identified by OBNet in breast cancer significantly overlap with modules identified from TCGA breast cancer gene expression study, revealing the power of OBNet in identifying biological processes involved in the disease. äUsing molecular functional networks to manifest connections between ob(epmc).pdf DeepDyve Pubget Overpricing