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10.1186/s13046-017-0623-0 http://scihub22266oqcxt.onion/10.1186/s13046-017-0623-0 C5688805!5688805!29115974     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Exp+Clin+Cancer+Res 2017 ; 36 (ä): ä Nephropedia Template TP {{tp|p=29115974|t=2017. STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC |pdf=|usr=}}{{29115974}} gab.com Text STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC JO: J Exp Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=29115974 #FOAvip Background: Whole-cell tumor vaccines have shown much promise; however, only limited success has been achieved for the goal of eliciting robust tumor-specific T-cell responses. Methods: Hepatocellular carcinoma (HCC) cells, H22 and Hepa1?6, were modified by blocking the STAT3 signaling pathway with a STAT3 decoy oligodeoxynucleotide, and the immunogenicity and possibility of using these cell lysates as a vaccine were evaluated. Results: STAT3-blocked whole HCC cell lysates inhibited tumor growth and tumorigenesis, and prolonged the survival of tumor-bearing mice. In addition, STAT3-blocked whole HCC cell lysates stimulated the activation of T cells and natural killer (NK) cells, and enhanced the infiltration of cytotoxic CD8+ T cells in the tumor tissues. In addition, the maturation of dendritic cells (DCs) was enhanced, which promoted the generation of immunological memory against HCC. Furthermore, secondary immune responses could be primed as soon as these immunized mice were challenged with HCC cells, accompanied by T cell and NK cell activation and infiltration. Additionally, immunization with this vaccine decreased the generation of Tregs and the production of TGF-? and IL-10. Importantly, STAT3-blocked whole HCC cell lysates prevented HCC-mediated exhaustion of T cells and NK cells, showing low expression of checkpoint molecules such as PD-1 and TIGIT on T cells and NK cells in the immunized mice. Conclusions: The newly generated STAT3-blocked whole-cell HCC vaccine has potential for cancer cell vaccination. Electronic supplementary material: The online version of this article (10.1186/s13046-017-0623-0) contains supplementary material, which is available to authorized users. Twit Text FOAVip STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC ????J Exp Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=29115974 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29115974 #FOAvip English Wikipedia <ref>{{Cite pmid|29115974}}</ref> STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC #MMPMID29115974 Han Q; Wang Y; Pang M; Zhang J J Exp Clin Cancer Res 2017[]; 36 (ä): ä PMID29115974show ga Background: Whole-cell tumor vaccines have shown much promise; however, only limited success has been achieved for the goal of eliciting robust tumor-specific T-cell responses. Methods: Hepatocellular carcinoma (HCC) cells, H22 and Hepa1?6, were modified by blocking the STAT3 signaling pathway with a STAT3 decoy oligodeoxynucleotide, and the immunogenicity and possibility of using these cell lysates as a vaccine were evaluated. Results: STAT3-blocked whole HCC cell lysates inhibited tumor growth and tumorigenesis, and prolonged the survival of tumor-bearing mice. In addition, STAT3-blocked whole HCC cell lysates stimulated the activation of T cells and natural killer (NK) cells, and enhanced the infiltration of cytotoxic CD8+ T cells in the tumor tissues. In addition, the maturation of dendritic cells (DCs) was enhanced, which promoted the generation of immunological memory against HCC. Furthermore, secondary immune responses could be primed as soon as these immunized mice were challenged with HCC cells, accompanied by T cell and NK cell activation and infiltration. Additionally, immunization with this vaccine decreased the generation of Tregs and the production of TGF-? and IL-10. Importantly, STAT3-blocked whole HCC cell lysates prevented HCC-mediated exhaustion of T cells and NK cells, showing low expression of checkpoint molecules such as PD-1 and TIGIT on T cells and NK cells in the immunized mice. Conclusions: The newly generated STAT3-blocked whole-cell HCC vaccine has potential for cancer cell vaccination. Electronic supplementary material: The online version of this article (10.1186/s13046-017-0623-0) contains supplementary material, which is available to authorized users. äSTAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral(epmc).pdf DeepDyve Pubget Overpricing