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10.1186/s12014-017-9172-y http://scihub22266oqcxt.onion/10.1186/s12014-017-9172-y C5688700!5688700!29176938     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29176938&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Proteomics 2017 ; 14 (ä): ä Nephropedia Template TP {{tp|p=29176938|t=2017. A proteomic approach to understanding the pathogenesis of idiopathic macular hole formation |pdf=|usr=}}{{29176938}} gab.com Text A proteomic approach to understanding the pathogenesis of idiopathic macular hole formation JO: Clin Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=29176938 #FOAvip Idiopathic macular holes (IMH) are full-thickness defects of retinal tissue that cause severe vision loss due to disruption of the anatomic fovea. Abnormal vitreous traction is involved in the formation of macular holes. Both glial cells and hyalocytes contribute to epiretinal membrane formation in IMH. In order to gain further insight into the pathophysiology of IMH, we conducted a discovery phase investigation of the vitreous proteome in four patients with macular holes and six controls using one-dimensional gel fractionation and liquid chromatography?tandem mass spectrometry analyses on an Orbitrap Elite mass spectrometer. Of a total of 5912 vitreous proteins, 32 proteins had increased and 39 proteins had decreased expression in IMH compared with controls, using a false discovery rate approach with p value < 0.001 and q value < 0.05. IMH was associated with increased expression of proteins in the complement pathway, ?-2-macroglobulin, a major inducer of Müller glial cell migration, fibrinogen, and extracellular matrix proteins, and decreased expression of proteins involved in protein folding and actin filament binding. A proteomic approach revealed proteins and biological pathways that may be involved in the pathogenesis of IMH and could be targeted for future studies.Electronic supplementary material: The online version of this article (10.1186/s12014-017-9172-y) contains supplementary material, which is available to authorized users. Twit Text FOAVip A proteomic approach to understanding the pathogenesis of idiopathic macular hole formation ????Clin Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=29176938 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29176938 #FOAvip English Wikipedia <ref>{{Cite pmid|29176938}}</ref> A proteomic approach to understanding the pathogenesis of idiopathic macular hole formation #MMPMID29176938 Zhang P; Zhu M; Zhao Y; Qian J; Dufresne C; Turner R; Semba RD; Solomon SD Clin Proteomics 2017[]; 14 (ä): ä PMID29176938show ga Idiopathic macular holes (IMH) are full-thickness defects of retinal tissue that cause severe vision loss due to disruption of the anatomic fovea. Abnormal vitreous traction is involved in the formation of macular holes. Both glial cells and hyalocytes contribute to epiretinal membrane formation in IMH. In order to gain further insight into the pathophysiology of IMH, we conducted a discovery phase investigation of the vitreous proteome in four patients with macular holes and six controls using one-dimensional gel fractionation and liquid chromatography?tandem mass spectrometry analyses on an Orbitrap Elite mass spectrometer. Of a total of 5912 vitreous proteins, 32 proteins had increased and 39 proteins had decreased expression in IMH compared with controls, using a false discovery rate approach with p value < 0.001 and q value < 0.05. IMH was associated with increased expression of proteins in the complement pathway, ?-2-macroglobulin, a major inducer of Müller glial cell migration, fibrinogen, and extracellular matrix proteins, and decreased expression of proteins involved in protein folding and actin filament binding. A proteomic approach revealed proteins and biological pathways that may be involved in the pathogenesis of IMH and could be targeted for future studies.Electronic supplementary material: The online version of this article (10.1186/s12014-017-9172-y) contains supplementary material, which is available to authorized users. äA proteomic approach to understanding the pathogenesis of idiopathic m(epmc).pdf DeepDyve Pubget Overpricing