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10.1042/BCJ20170377 http://scihub22266oqcxt.onion/10.1042/BCJ20170377 C5688466!5688466!29146872     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+J 2017 ; 474 (23): 3935-50 Nephropedia Template TP {{tp|p=29146872|t=2017. Holistic bioengineering: rewiring central metabolism for enhanced bioproduction |pdf=|usr=}}{{29146872}} gab.com Text Holistic bioengineering: rewiring central metabolism for enhanced bioproduction JO: Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=29146872 #FOAvip What does it take to convert a living organism into a truly productive biofactory? Apart from optimizing biosynthesis pathways as standalone units, a successful bioengineering approach must bend the endogenous metabolic network of the host, and especially its central metabolism, to support the bioproduction process. In practice, this usually involves three complementary strategies which include tuning-down or abolishing competing metabolic pathways, increasing the availability of precursors of the desired biosynthesis pathway, and ensuring high availability of energetic resources such as ATP and NADPH. In this review, we explore these strategies, focusing on key metabolic pathways and processes, such as glycolysis, anaplerosis, the TCA (tricarboxylic acid) cycle, and NADPH production. We show that only a holistic approach for bioengineering ? considering the metabolic network of the host organism as a whole, rather than focusing on the production pathway alone ? can truly mold microorganisms into efficient biofactories. Twit Text FOAVip Holistic bioengineering: rewiring central metabolism for enhanced bioproduction ????Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=29146872 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29146872 #FOAvip English Wikipedia <ref>{{Cite pmid|29146872}}</ref> Holistic bioengineering: rewiring central metabolism for enhanced bioproduction #MMPMID29146872 Aslan S; Noor E; Bar-Even A Biochem J 2017[Dec]; 474 (23): 3935-50 PMID29146872show ga What does it take to convert a living organism into a truly productive biofactory? Apart from optimizing biosynthesis pathways as standalone units, a successful bioengineering approach must bend the endogenous metabolic network of the host, and especially its central metabolism, to support the bioproduction process. In practice, this usually involves three complementary strategies which include tuning-down or abolishing competing metabolic pathways, increasing the availability of precursors of the desired biosynthesis pathway, and ensuring high availability of energetic resources such as ATP and NADPH. In this review, we explore these strategies, focusing on key metabolic pathways and processes, such as glycolysis, anaplerosis, the TCA (tricarboxylic acid) cycle, and NADPH production. We show that only a holistic approach for bioengineering ? considering the metabolic network of the host organism as a whole, rather than focusing on the production pathway alone ? can truly mold microorganisms into efficient biofactories. äHolistic bioengineering: rewiring central metabolism for enhanced biop(epmc).pdf DeepDyve Pubget Overpricing