Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41467-017-01771-2 http://scihub22266oqcxt.onion/10.1038/s41467-017-01771-2 C5688161!5688161 !29142230     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29142230 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 1510 Nephropedia Template TP {{tp|p=29142230 |t=2017. Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis |pdf=|usr=}}{{29142230 }} gab.com Text Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29142230 #FOAvip Spondyloarthritis encompasses a group of common inflammatory diseases thought to be driven by IL-17A-secreting type-17 lymphocytes. Here we show increased numbers of GM-CSF-producing CD4 and CD8 lymphocytes in the blood and joints of patients with spondyloarthritis, and increased numbers of IL-17A(+)GM-CSF(+) double-producing CD4, CD8, ?? and NK cells. GM-CSF production in CD4 T cells occurs both independently and in combination with classical Th1 and Th17 cytokines. Type 3 innate lymphoid cells producing predominantly GM-CSF are expanded in synovial tissues from patients with spondyloarthritis. GM-CSF(+)CD4(+) cells, isolated using a triple cytokine capture approach, have a specific transcriptional signature. Both GM-CSF(+) and IL-17A(+)GM-CSF(+) double-producing CD4 T cells express increased levels of GPR65, a proton-sensing receptor associated with spondyloarthritis in genome-wide association studies and pathogenicity in murine inflammatory disease models. Silencing GPR65 in primary CD4 T cells reduces GM-CSF production. GM-CSF and GPR65 may thus serve as targets for therapeutic intervention of spondyloarthritis. Twit Text FOAVip Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29142230 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29142230 #FOAvip English Wikipedia <ref>{{Cite pmid|29142230 }}</ref> Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis #MMPMID29142230 Al-Mossawi MH ; Chen L ; Fang H ; Ridley A ; de Wit J ; Yager N ; Hammitzsch A ; Pulyakhina I ; Fairfax BP ; Simone D ; Yi Y ; Bandyopadhyay S ; Doig K ; Gundle R ; Kendrick B ; Powrie F ; Knight JC ; Bowness P Nat Commun 2017[Nov]; 8 (1 ): 1510 PMID29142230 show ga Spondyloarthritis encompasses a group of common inflammatory diseases thought to be driven by IL-17A-secreting type-17 lymphocytes. Here we show increased numbers of GM-CSF-producing CD4 and CD8 lymphocytes in the blood and joints of patients with spondyloarthritis, and increased numbers of IL-17A(+)GM-CSF(+) double-producing CD4, CD8, ?? and NK cells. GM-CSF production in CD4 T cells occurs both independently and in combination with classical Th1 and Th17 cytokines. Type 3 innate lymphoid cells producing predominantly GM-CSF are expanded in synovial tissues from patients with spondyloarthritis. GM-CSF(+)CD4(+) cells, isolated using a triple cytokine capture approach, have a specific transcriptional signature. Both GM-CSF(+) and IL-17A(+)GM-CSF(+) double-producing CD4 T cells express increased levels of GPR65, a proton-sensing receptor associated with spondyloarthritis in genome-wide association studies and pathogenicity in murine inflammatory disease models. Silencing GPR65 in primary CD4 T cells reduces GM-CSF production. GM-CSF and GPR65 may thus serve as targets for therapeutic intervention of spondyloarthritis. |*Transcriptome [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Animals [MESH] |CD4-Positive T-Lymphocytes/*metabolism [MESH] |Female [MESH] |Genome-Wide Association Study [MESH] |Granulocyte-Macrophage Colony-Stimulating Factor/*genetics/metabolism [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Middle Aged [MESH] |Receptors, G-Protein-Coupled/genetics/metabolism [MESH] |Spondylarthritis/*genetics/metabolism [MESH]Unique transcriptome signatures and GM-CSF expression in lymphocytes f(epmc).pdf DeepDyve Pubget Overpricing