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10.1038/s41467-017-01574-5 http://scihub22266oqcxt.onion/10.1038/s41467-017-01574-5 C5688148!5688148 !29142193     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29142193 &cmd=llinks): Failed to open stream: HTTP request failed! 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PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer |pdf=|usr=}}{{29142193 }} gab.com Text PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29142193 #FOAvip PTEN activity is often lost in prostate cancer. We show that the tyrosine kinase PTK6 (BRK) is a PTEN substrate. Phosphorylation of PTK6 tyrosine 342 (PY342) promotes activation, while phosphorylation of tyrosine 447 (PY447) regulates auto-inhibition. Introduction of PTEN into a PTEN null prostate cancer cell line leads to dephosphorylation of PY342 but not PY447 and PTK6 inhibition. Conversely, PTEN knockdown promotes PTK6 activation in PTEN positive cells. Using a variety of PTEN mutant constructs, we show that protein phosphatase activity of PTEN targets PTK6, with efficiency similar to PTP1B, a phosphatase that directly dephosphorylates PTK6 Y342. Conditional disruption of Pten in the mouse prostate leads to tumorigenesis and increased phosphorylation of PTK6 Y342, and disruption of Ptk6 impairs tumorigenesis. In human prostate tumor tissue microarrays, loss of PTEN correlates with increased PTK6 PY342 and poor outcome. These data suggest PTK6 activation promotes invasive prostate cancer induced by PTEN loss. Twit Text FOAVip PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29142193 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29142193 #FOAvip English Wikipedia <ref>{{Cite pmid|29142193 }}</ref> PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer #MMPMID29142193 Wozniak DJ ; Kajdacsy-Balla A ; Macias V ; Ball-Kell S ; Zenner ML ; Bie W ; Tyner AL Nat Commun 2017[Nov]; 8 (1 ): 1508 PMID29142193 show ga PTEN activity is often lost in prostate cancer. We show that the tyrosine kinase PTK6 (BRK) is a PTEN substrate. Phosphorylation of PTK6 tyrosine 342 (PY342) promotes activation, while phosphorylation of tyrosine 447 (PY447) regulates auto-inhibition. Introduction of PTEN into a PTEN null prostate cancer cell line leads to dephosphorylation of PY342 but not PY447 and PTK6 inhibition. Conversely, PTEN knockdown promotes PTK6 activation in PTEN positive cells. Using a variety of PTEN mutant constructs, we show that protein phosphatase activity of PTEN targets PTK6, with efficiency similar to PTP1B, a phosphatase that directly dephosphorylates PTK6 Y342. Conditional disruption of Pten in the mouse prostate leads to tumorigenesis and increased phosphorylation of PTK6 Y342, and disruption of Ptk6 impairs tumorigenesis. In human prostate tumor tissue microarrays, loss of PTEN correlates with increased PTK6 PY342 and poor outcome. These data suggest PTK6 activation promotes invasive prostate cancer induced by PTEN loss. |*Signal Transduction [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mutation [MESH] |Neoplasm Proteins/genetics/*metabolism [MESH] |PTEN Phosphohydrolase/genetics/*metabolism [MESH] |Phosphorylation [MESH] |Protein-Tyrosine Kinases/genetics/*metabolism [MESH]PTEN is a protein phosphatase that targets active PTK6 and inhibits PT(epmc).pdf DeepDyve Pubget Overpricing