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10.1038/s41598-017-15755-1 http://scihub22266oqcxt.onion/10.1038/s41598-017-15755-1 C5688086!5688086 !29142235     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29142235 &cmd=llinks): Failed to open stream: HTTP request failed! 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Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia |pdf=|usr=}}{{29142235 }} gab.com Text Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29142235 #FOAvip Sepsis is a life-threatening disorder characterized by organ dysfunction and a major cause of mortality worldwide. The major challenge in studying sepsis is its diversity in such factors as age, source of infection and etiology. Recently, genomic and proteomic approaches have improved our understanding of its complex pathogenesis. In the present study, we use quantitative proteomics to evaluate the host proteome response in septic patients secondary to community-acquired pneumonia (CAP). Samples obtained at admission and after 7 days of follow-up were analyzed according to the outcomes of septic patients. The patients' proteome profiles were compared with age- and gender-matched healthy volunteers. Bioinformatic analyses of differentially expressed proteins showed alteration in the cytoskeleton, cellular assembly, movement, lipid metabolism and immune responses in septic patients. Actin and gelsolin changes were assessed in mononuclear cells using immunofluorescence, and a higher expression of gelsolin and depletion of actin were observed in survivor patients. Regarding lipid metabolism, changes in cholesterol, HDL and apolipoproteins were confirmed using enzymatic colorimetric methods in plasma. Transcriptomic studies revealed a massive change in gene expression in sepsis. Our proteomic results stressed important changes in cellular structure and metabolism, which are possible targets for future interventions of sepsis. Twit Text FOAVip Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29142235 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29142235 #FOAvip English Wikipedia <ref>{{Cite pmid|29142235 }}</ref> Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia #MMPMID29142235 Sharma NK ; Tashima AK ; Brunialti MKC ; Ferreira ER ; Torquato RJS ; Mortara RA ; Machado FR ; Assuncao M ; Rigato O ; Salomao R Sci Rep 2017[Nov]; 7 (1 ): 15606 PMID29142235 show ga Sepsis is a life-threatening disorder characterized by organ dysfunction and a major cause of mortality worldwide. The major challenge in studying sepsis is its diversity in such factors as age, source of infection and etiology. Recently, genomic and proteomic approaches have improved our understanding of its complex pathogenesis. In the present study, we use quantitative proteomics to evaluate the host proteome response in septic patients secondary to community-acquired pneumonia (CAP). Samples obtained at admission and after 7 days of follow-up were analyzed according to the outcomes of septic patients. The patients' proteome profiles were compared with age- and gender-matched healthy volunteers. Bioinformatic analyses of differentially expressed proteins showed alteration in the cytoskeleton, cellular assembly, movement, lipid metabolism and immune responses in septic patients. Actin and gelsolin changes were assessed in mononuclear cells using immunofluorescence, and a higher expression of gelsolin and depletion of actin were observed in survivor patients. Regarding lipid metabolism, changes in cholesterol, HDL and apolipoproteins were confirmed using enzymatic colorimetric methods in plasma. Transcriptomic studies revealed a massive change in gene expression in sepsis. Our proteomic results stressed important changes in cellular structure and metabolism, which are possible targets for future interventions of sepsis. |Actins/genetics [MESH] |Aged [MESH] |Community-Acquired Infections/blood/complications/*genetics/pathology [MESH] |Female [MESH] |Gelsolin/genetics [MESH] |Gene Expression Regulation/genetics [MESH] |Genome, Human/genetics [MESH] |Genomics [MESH] |Host-Pathogen Interactions/genetics [MESH] |Humans [MESH] |Lipid Metabolism/*genetics [MESH] |Lipids/blood [MESH] |Male [MESH] |Middle Aged [MESH] |Pneumonia/blood/complications/*genetics/pathology [MESH] |Proteome/genetics [MESH] |Sepsis/blood/complications/*genetics/pathology [MESH]Proteomic study revealed cellular assembly and lipid metabolism dysreg(epmc).pdf DeepDyve Pubget Overpricing