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10.1038/s41598-017-15546-8 http://scihub22266oqcxt.onion/10.1038/s41598-017-15546-8 C5688061!5688061 !29142309     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29142309 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 15655 Nephropedia Template TP {{tp|p=29142309 |t=2017. Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population |pdf=|usr=}}{{29142309 }} gab.com Text Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29142309 #FOAvip Hypercholesterolemia promotes the inflammation against lipoproteins in atherosclerosis. Development of atherosclerosis is affected by the balance between pro-inflammatory effector T cells and anti-inflammatory regulatory T (Treg) cells. However, phenotype and function of T cell subpopulations in hypercholesterolemia remain to be investigated. Here, we found that cholesterol-containing diet increased the expression of the Treg cell lineage-defining transcription factor FoxP3 among thymocytes and splenocytes. Hypercholesterolemia elevated the FoxP3 expression level and population size of peripheral Treg cells, but did not prevent enhanced proliferation of stimulated T cells. Moreover, cholesterol supplementation in diet as well as in cell culture medium promoted T cell antigen receptor (TCR) signaling in CD4+ T cells. Our results demonstrate that hypercholesterolemia enhances TCR stimulation, Treg cell development as well as T cell proliferation. Thus, our findings may help to understand why hypercholesterolemia correlates with altered CD4+ T cell responses. Twit Text FOAVip Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29142309 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29142309 #FOAvip English Wikipedia <ref>{{Cite pmid|29142309 }}</ref> Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population #MMPMID29142309 Mailer RKW ; Gisterå A ; Polyzos KA ; Ketelhuth DFJ ; Hansson GK Sci Rep 2017[Nov]; 7 (1 ): 15655 PMID29142309 show ga Hypercholesterolemia promotes the inflammation against lipoproteins in atherosclerosis. Development of atherosclerosis is affected by the balance between pro-inflammatory effector T cells and anti-inflammatory regulatory T (Treg) cells. However, phenotype and function of T cell subpopulations in hypercholesterolemia remain to be investigated. Here, we found that cholesterol-containing diet increased the expression of the Treg cell lineage-defining transcription factor FoxP3 among thymocytes and splenocytes. Hypercholesterolemia elevated the FoxP3 expression level and population size of peripheral Treg cells, but did not prevent enhanced proliferation of stimulated T cells. Moreover, cholesterol supplementation in diet as well as in cell culture medium promoted T cell antigen receptor (TCR) signaling in CD4+ T cells. Our results demonstrate that hypercholesterolemia enhances TCR stimulation, Treg cell development as well as T cell proliferation. Thus, our findings may help to understand why hypercholesterolemia correlates with altered CD4+ T cell responses. |Animals [MESH] |Atherosclerosis/genetics/*immunology/pathology [MESH] |CD4-Positive T-Lymphocytes/drug effects/immunology [MESH] |Cell Lineage/immunology [MESH] |Cholesterol, Dietary/pharmacology [MESH] |Forkhead Transcription Factors/*genetics/immunology [MESH] |Humans [MESH] |Hypercholesterolemia/genetics/*immunology/pathology [MESH] |Inflammation/genetics/*immunology/pathology [MESH] |Lipoproteins/metabolism [MESH] |Mice, Knockout [MESH] |Receptors, Antigen, T-Cell/*genetics/immunology [MESH] |Receptors, LDL/genetics [MESH] |Signal Transduction/immunology [MESH] |T-Lymphocytes, Regulatory/immunology [MESH] |T-Lymphocytes/immunology [MESH]Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases (epmc).pdf DeepDyve Pubget Overpricing