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2017 ; 8
(51
): 89119-89129
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Risk factors associated with fatality of severe fever with thrombocytopenia
syndrome: a meta-analysis
#MMPMID29179504
Chen Y
; Jia B
; Liu Y
; Huang R
; Chen J
; Wu C
Oncotarget
2017[Oct]; 8
(51
): 89119-89129
PMID29179504
show ga
Severe fever with thrombocytopenia syndrome is an emerging life-threatening
infectious disease identified in 2009. Given high case-fatality rate among
patients with severe fever with thrombocytopenia syndrome, identification of the
risk factors at acute phase associated with fatality is crucial for treatment.
Therefore, we aimed to meta-analytically evaluate risk factors of fatal clinical
outcome of severe fever with thrombocytopenia syndrome. 238 fatal cases and 873
non-fatal cases from 12 studies were included in this meta-analysis. Elder age
and high viral load were significantly associated with fatal clinical outcome.
Further, severe fever with thrombocytopenia syndrome patients with fatal clinical
outcome had significantly reduced level of albumin and platelet count, higher
level of serum alanine aminotransferase, aspirate aminotransferase, lactic acid
dehydrogenase and creatinine phosphokinase, and prolonged activated partial
thromboplastin time, comparing with mild patients. These disturbed parameters
function as predictors to warn fatal clinical outcome of the disease. Moreover,
ribavirin has a minimal impact to alleviate disease progression of severe fever
with thrombocytopenia syndrome. In conclusion, our finding demonstrates a panel
of factors associated with fatality of SFTS disease, which have important
implications during clinical practice.