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10.18632/oncotarget.21640 http://scihub22266oqcxt.onion/10.18632/oncotarget.21640 C5687663!5687663!29179493     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29179493.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (51): 88988-9004 Nephropedia Template TP {{tp|p=29179493|t=2017. Sphingosine kinase 1 mediates diabetic renal fibrosis via NF-?B signaling pathway: involvement of CK2? |pdf=|usr=}}{{29179493}} gab.com Text Sphingosine kinase 1 mediates diabetic renal fibrosis via NF- B signaling pathway: involvement of CK2 JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29179493 #FOAvip Sphingosine kinase 1 (SphK1) plays a pivotal role in regulating diabetic renal fibrotic factors such as fibronectin (FN) and intercellular adhesion molecule-1 (ICAM-1). Especially, activation of SphK1 is closely linked to the body inflammatory reaction. Casein kinase 2? subunit (CK2?), a protein kinase related to inflammatory reaction, influences diabetic renal fibrosis and expressions of FN and ICAM-1 via NF-?B pathway. However, the mechanism by which SphK1 mediates diabetic renal fibrosis has not yet fully elucidated. The current study is aimed to investigate if SphK1 mediates diabetic renal fibrotic pathological process via inflammatory pathway and activation of CK2?. The following findings were observed: (1) Expressions of SphK1 were upregulated in kidneys of diabetic mice and rats; (2) Knockdown of SphK1 expression suppressed high glucose (HG)-induced NF-?B nuclear translocation and expressions of FN and ICAM-1; (3) Compared with C57 diabetic mice, SphK1-/- diabetic mice exhibited less renal fibrotic lesions, FN accumulation and NF-?B nuclear accumulation in glomeruli of kidneys; (4) SphK1 mediated phosphorylation of CK2?, while CK2? knockdown depressed SphK1-induced activation of NF-?B pathway. This study indicates the essential role of SphK1 in regulating activation of CK2? and diabetic renal fibrotic pathological process via NF-?B. Twit Text FOAVip Sphingosine kinase 1 mediates diabetic renal fibrosis via NF- B signaling pathway: involvement of CK2 ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29179493 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29179493 #FOAvip English Wikipedia <ref>{{Cite pmid|29179493}}</ref> Sphingosine kinase 1 mediates diabetic renal fibrosis via NF-?B signaling pathway: involvement of CK2? #MMPMID29179493 Huang J; Li J; Chen Z; Li J; Chen Q; Gong W; Liu P; Huang H Oncotarget 2017[Oct]; 8 (51): 88988-9004 PMID29179493show ga Sphingosine kinase 1 (SphK1) plays a pivotal role in regulating diabetic renal fibrotic factors such as fibronectin (FN) and intercellular adhesion molecule-1 (ICAM-1). Especially, activation of SphK1 is closely linked to the body inflammatory reaction. Casein kinase 2? subunit (CK2?), a protein kinase related to inflammatory reaction, influences diabetic renal fibrosis and expressions of FN and ICAM-1 via NF-?B pathway. However, the mechanism by which SphK1 mediates diabetic renal fibrosis has not yet fully elucidated. The current study is aimed to investigate if SphK1 mediates diabetic renal fibrotic pathological process via inflammatory pathway and activation of CK2?. The following findings were observed: (1) Expressions of SphK1 were upregulated in kidneys of diabetic mice and rats; (2) Knockdown of SphK1 expression suppressed high glucose (HG)-induced NF-?B nuclear translocation and expressions of FN and ICAM-1; (3) Compared with C57 diabetic mice, SphK1-/- diabetic mice exhibited less renal fibrotic lesions, FN accumulation and NF-?B nuclear accumulation in glomeruli of kidneys; (4) SphK1 mediated phosphorylation of CK2?, while CK2? knockdown depressed SphK1-induced activation of NF-?B pathway. This study indicates the essential role of SphK1 in regulating activation of CK2? and diabetic renal fibrotic pathological process via NF-?B. äSphingosine kinase 1 mediates diabetic renal fibrosis via NF-?B signal(epmc).pdf DeepDyve Pubget Overpricing