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10.18632/oncotarget.19917 http://scihub22266oqcxt.onion/10.18632/oncotarget.19917 C5687608!5687608!29179438     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (51): 88332-44 Nephropedia Template TP {{tp|p=29179438|t=2017. Valproate hampers podocyte acquisition of immune phenotypes via intercepting the GSK3? facilitated NFkB activation |pdf=|usr=}}{{29179438}} gab.com Text Valproate hampers podocyte acquisition of immune phenotypes via intercepting the GSK3 facilitated NFkB activation JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29179438 #FOAvip Glomerular podocytes are able to transdifferentiate under disease conditions, acquire de novo immune phenotypes and behave as immunocompetent cells, like phagocytes or antigen-presenting cells. Upon stimulation with lipopolysaccharide (LPS), a prototypical pathogen-associated molecular pattern, podocytes demonstrated de novo expression of a variety of NFkB-dependent immune molecules that are pivotal for immune response, including major histocompatibility complex (MHC) class II, costimulatory molecule CD80, lysosomal protease cathepsin L as well as CC chemokine ligand 2 and 5, ultimately resulting in podocyte dysfunction, characterized by cellular shrinkage, a spindle-like or asterlike cell shape and impairment of actin cytoskeleton integrity. The LPS-elicited podocyte phenotypic changes were concurrent with nuclear factor (NF) kB phosphorylation, which was associated with glycogen synthase kinase (GSK) 3? overactivity, marked by a diminished inhibitory phosphorylation of GSK3?. In contrast, valproate, an anticonvulsant and mood stabilizer, offset GSK3? overactivity in LPS-injured podocytes and mitigated NFkB activation and podocyte acquisition of immune phenotypes as well as the ensuing cytopathic changes, podocyte cytoskeleton disorganization and dysfunction. The protective effect of valproate was strikingly blunted in podocytes expressing the constitutively active GSK3?, suggesting an essential role of inhibitory phosphorylation of GSK3?. In vivo in LPS-injured mice, valproate therapy abolished GSK3? overactivity in glomeruli and attenuated podocyte injury and albuminuria, concomitant with a lessened NFkB activation and diminished induction of diverse podocytopathic immune molecules in podocytes and glomeruli. Taken together, valproate directly protects against podocyte injury and hampers podocyte acquisition of de novo immune phenotypes via intercepting the GSK3? facilitated NFkB activation. Twit Text FOAVip Valproate hampers podocyte acquisition of immune phenotypes via intercepting the GSK3 facilitated NFkB activation ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29179438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29179438 #FOAvip English Wikipedia <ref>{{Cite pmid|29179438}}</ref> Valproate hampers podocyte acquisition of immune phenotypes via intercepting the GSK3? facilitated NFkB activation #MMPMID29179438 Wang P; Zhou S; Ge Y; Lu M; Liu Z; Gong R Oncotarget 2017[Oct]; 8 (51): 88332-44 PMID29179438show ga Glomerular podocytes are able to transdifferentiate under disease conditions, acquire de novo immune phenotypes and behave as immunocompetent cells, like phagocytes or antigen-presenting cells. Upon stimulation with lipopolysaccharide (LPS), a prototypical pathogen-associated molecular pattern, podocytes demonstrated de novo expression of a variety of NFkB-dependent immune molecules that are pivotal for immune response, including major histocompatibility complex (MHC) class II, costimulatory molecule CD80, lysosomal protease cathepsin L as well as CC chemokine ligand 2 and 5, ultimately resulting in podocyte dysfunction, characterized by cellular shrinkage, a spindle-like or asterlike cell shape and impairment of actin cytoskeleton integrity. The LPS-elicited podocyte phenotypic changes were concurrent with nuclear factor (NF) kB phosphorylation, which was associated with glycogen synthase kinase (GSK) 3? overactivity, marked by a diminished inhibitory phosphorylation of GSK3?. In contrast, valproate, an anticonvulsant and mood stabilizer, offset GSK3? overactivity in LPS-injured podocytes and mitigated NFkB activation and podocyte acquisition of immune phenotypes as well as the ensuing cytopathic changes, podocyte cytoskeleton disorganization and dysfunction. The protective effect of valproate was strikingly blunted in podocytes expressing the constitutively active GSK3?, suggesting an essential role of inhibitory phosphorylation of GSK3?. In vivo in LPS-injured mice, valproate therapy abolished GSK3? overactivity in glomeruli and attenuated podocyte injury and albuminuria, concomitant with a lessened NFkB activation and diminished induction of diverse podocytopathic immune molecules in podocytes and glomeruli. Taken together, valproate directly protects against podocyte injury and hampers podocyte acquisition of de novo immune phenotypes via intercepting the GSK3? facilitated NFkB activation. äValproate hampers podocyte acquisition of immune phenotypes via interc(epmc).pdf DeepDyve Pubget Overpricing