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10.1136/rmdopen-2017-000550

http://scihub22266oqcxt.onion/10.1136/rmdopen-2017-000550
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suck abstract from ncbi


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pmid29177082
      RMD+Open 2017 ; 3 (2 ): e000550
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  • Autoimmune-autoinflammatory rheumatoid arthritis overlaps: a rare but potentially important subgroup of diseases #MMPMID29177082
  • Savic S ; Mistry A ; Wilson AG ; Barcenas-Morales G ; Doffinger R ; Emery P ; McGonagle D
  • RMD Open 2017[]; 3 (2 ): e000550 PMID29177082 show ga
  • At the population level, rheumatoid arthritis (RA) is generally viewed as autoimmune in nature with a small subgroup of cases having a palindromic form or systemic autoinflammatory disorder (SAID) phenotype. Herein, we describe resistant cases of classical autoantibody associated RA that had clinical, genetic and therapeutic responses indicative of coexistent autoinflammatory disease. Five patients with clinically overlapping features between RA and SAID including polysynovitis and autoantibody/shared epitope positivity, and who had abrupt severe self-limiting attacks including fevers and serositis, are described. Mutations or single nucleotide polymorphisms in recognised autoinflammatory pathways were evident. Generally, these cases responded poorly to conventional Disease-modifying anti-rheumatic drugs (DMARD) treatment with some excellent responses to colchicine or interleukin 1 pathway blockade. A subgroup of RA cases have a mixed autoimmune-autoinflammatory phenotype and genotype with therapeutic implications.
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