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10.2147/DDDT.S149504 http://scihub22266oqcxt.onion/10.2147/DDDT.S149504 C5687495!5687495 !29184392     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29184392 &cmd=llinks): Failed to open stream: HTTP request failed! 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Paeoniflorin attenuates incipient diabetic nephropathy in streptozotocin-induced mice by the suppression of the Toll-like receptor-2 signaling pathway |pdf=|usr=}}{{29184392 }} gab.com Text Paeoniflorin attenuates incipient diabetic nephropathy in streptozotocin-induced mice by the suppression of the Toll-like receptor-2 signaling pathway JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=29184392 #FOAvip Toll-like receptors (TLRs) may be involved in diabetic nephropathy (DN). Paeoniflorin (PF) is an effective Chinese traditional medicine with anti-inflammatory and immunoregulatory effects that may inhibit the TLR2 signaling pathway. In this study, we investigated the effects of PF on the kidneys of mice with streptozotocin-induced type 1 diabetes mellitus using TLR2 knockout mice (TLR2(-/-)) and wild-type littermates (C57BL/6J-WT). After 12 weeks of intraperitoneal injection of PF at doses of 25, 50, and 100 mg/kg once a day, diabetic mice had significantly reduced albuminuria and attenuated renal histopathology. These changes were associated with substantially alleviated macrophage infiltration and decreased expression of TLR2 signaling pathway biomarkers. These data support a role of TLR2 in promoting inflammation and indicate that the effect of PF is associated with the inhibition of the TLR2 pathway in the kidneys of diabetic mice. PF thus shows therapeutic potential for the prevention and treatment of DN. Twit Text FOAVip Paeoniflorin attenuates incipient diabetic nephropathy in streptozotocin-induced mice by the suppression of the Toll-like receptor-2 signaling pathway ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=29184392 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29184392 #FOAvip English Wikipedia <ref>{{Cite pmid|29184392 }}</ref> Paeoniflorin attenuates incipient diabetic nephropathy in streptozotocin-induced mice by the suppression of the Toll-like receptor-2 signaling pathway #MMPMID29184392 Shao YX ; Xu XX ; Wang K ; Qi XM ; Wu YG Drug Des Devel Ther 2017[]; 11 (ä): 3221-3233 PMID29184392 show ga Toll-like receptors (TLRs) may be involved in diabetic nephropathy (DN). Paeoniflorin (PF) is an effective Chinese traditional medicine with anti-inflammatory and immunoregulatory effects that may inhibit the TLR2 signaling pathway. In this study, we investigated the effects of PF on the kidneys of mice with streptozotocin-induced type 1 diabetes mellitus using TLR2 knockout mice (TLR2(-/-)) and wild-type littermates (C57BL/6J-WT). After 12 weeks of intraperitoneal injection of PF at doses of 25, 50, and 100 mg/kg once a day, diabetic mice had significantly reduced albuminuria and attenuated renal histopathology. These changes were associated with substantially alleviated macrophage infiltration and decreased expression of TLR2 signaling pathway biomarkers. These data support a role of TLR2 in promoting inflammation and indicate that the effect of PF is associated with the inhibition of the TLR2 pathway in the kidneys of diabetic mice. PF thus shows therapeutic potential for the prevention and treatment of DN. |Animals [MESH] |Anti-Inflammatory Agents, Non-Steroidal/chemistry/*pharmacology [MESH] |Diabetic Nephropathies/chemically induced/*drug therapy/pathology [MESH] |Dose-Response Relationship, Drug [MESH] |Glucosides/chemistry/*pharmacology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Molecular Conformation [MESH] |Monoterpenes/chemistry/*pharmacology [MESH] |Signal Transduction/*drug effects [MESH] |Streptozocin [MESH] |Structure-Activity Relationship [MESH]Paeoniflorin attenuates incipient diabetic nephropathy in streptozotoc(epmc).pdf DeepDyve Pubget Overpricing