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10.1017/erm.2017.8

http://scihub22266oqcxt.onion/10.1017/erm.2017.8
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C5687181!5687181!28716159
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suck abstract from ncbi


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pmid28716159      Expert+Rev+Mol+Med 2017 ; 19 (ä): ä
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  • Bilateral Wilms tumour: a review of clinical and molecular features #MMPMID28716159
  • Charlton J; Irtan S; Bergeron C; Pritchard-Jones K
  • Expert Rev Mol Med 2017[]; 19 (ä): ä PMID28716159show ga
  • Wilms tumour (WT) is the most common paediatric kidney cancer and affects approximately one in 10 000 children. The tumour is associated with undifferentiated embryonic lesions called nephrogenic rests (NRs) or, when diffuse, nephroblastomatosis. WT or NRs can occur in both kidneys, termed bilateral disease, found in only 5?8% of cases. Management of bilateral WT presents a major clinical challenge in terms of maximising survival, preserving renal function and understanding underlying genetic risk. In this review, we compile clinical data from 545 published cases of bilateral WT and discuss recent progress in understanding the molecular basis of bilateral WT and its associated precursor NRs in the context of the latest radiological, surgical and epidemiological features.
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