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10.1186/s12974-017-0999-y http://scihub22266oqcxt.onion/10.1186/s12974-017-0999-y C5686947!5686947!29137628     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neuroinflammation 2017 ; 14 (ä): ä Nephropedia Template TP {{tp|p=29137628|t=2017. Hypertonic saline for prevention of delirium in geriatric patients who underwent hip surgery |pdf=|usr=}}{{29137628}} gab.com Text Hypertonic saline for prevention of delirium in geriatric patients who underwent hip surgery JO: J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=29137628 #FOAvip Background: Postoperative delirium (POD) is a common disorder in the elderly patients, and neuroinflammation is the possible underlying mechanism. This study is designed to determine whether or not hypertonic saline (HS) pre-injection can alleviate POD in aged patients. Methods: This prospective study recruited 120 geriatric patients who underwent hip surgery. The patients were randomly divided into two groups: control group (NS group) and HS group. Patients in the NS group were pre-injected with 4 mL/kg isotonic saline, and those in the HS group were pre-injected with 4 mL/kg 7.5% HS. All 120 patients were then subjected to general anesthesia. Blood samples were extracted to detect the concentration of inflammatory factors, namely, IL-1?, IL-6, IL-10, and TNF-?, and the nerve injury factor S100?. Flow cytometry was used to detect the number of monocytes in peripheral venous blood and evaluate the relationship of inflammation to delirium. The nursing delirium screening scale (Nu-DESC) was used to determine cognitive function 1 to 3 days postoperatively. Results: Analysis using random-effect multivariable logistic regression indicated that HS administration before anesthesia was associated with a low risk of POD (odds ratio [OR], 0.13; 95% CI, 0.04 to 0.41; P?=?0.001) and few CD14?+?CD16+ monocytes (??=???0.61; 95% CI, ??0.74 to ??0.48; P?=?0.000) the following day. When the association between HS and delirium was controlled for CD14?+?CD16+ monocytes, the effect size became nonsignificant (odds ratio [OR], 0.86; 95% CI, 0.14 to 5.33; P?=?0.874). TNF-? was significantly associated with POD (odds ratio [OR], 1.10; 95% CI, 1.05 to 1.16; P?=?0.000). However, IL-1?, IL-6, IL-10, and S100? were not significantly related to POD. Conclusion: HS can alleviate POD in geriatric patients and may inhibit the secretion of inflammatory factors by monocytes. Twit Text FOAVip Hypertonic saline for prevention of delirium in geriatric patients who underwent hip surgery ????J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=29137628 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29137628 #FOAvip English Wikipedia <ref>{{Cite pmid|29137628}}</ref> Hypertonic saline for prevention of delirium in geriatric patients who underwent hip surgery #MMPMID29137628 Xin X; Xin F; Chen X; Zhang Q; Li Y; Huo S; Chang C; Wang Q J Neuroinflammation 2017[]; 14 (ä): ä PMID29137628show ga Background: Postoperative delirium (POD) is a common disorder in the elderly patients, and neuroinflammation is the possible underlying mechanism. This study is designed to determine whether or not hypertonic saline (HS) pre-injection can alleviate POD in aged patients. Methods: This prospective study recruited 120 geriatric patients who underwent hip surgery. The patients were randomly divided into two groups: control group (NS group) and HS group. Patients in the NS group were pre-injected with 4 mL/kg isotonic saline, and those in the HS group were pre-injected with 4 mL/kg 7.5% HS. All 120 patients were then subjected to general anesthesia. Blood samples were extracted to detect the concentration of inflammatory factors, namely, IL-1?, IL-6, IL-10, and TNF-?, and the nerve injury factor S100?. Flow cytometry was used to detect the number of monocytes in peripheral venous blood and evaluate the relationship of inflammation to delirium. The nursing delirium screening scale (Nu-DESC) was used to determine cognitive function 1 to 3 days postoperatively. Results: Analysis using random-effect multivariable logistic regression indicated that HS administration before anesthesia was associated with a low risk of POD (odds ratio [OR], 0.13; 95% CI, 0.04 to 0.41; P?=?0.001) and few CD14?+?CD16+ monocytes (??=???0.61; 95% CI, ??0.74 to ??0.48; P?=?0.000) the following day. When the association between HS and delirium was controlled for CD14?+?CD16+ monocytes, the effect size became nonsignificant (odds ratio [OR], 0.86; 95% CI, 0.14 to 5.33; P?=?0.874). TNF-? was significantly associated with POD (odds ratio [OR], 1.10; 95% CI, 1.05 to 1.16; P?=?0.000). However, IL-1?, IL-6, IL-10, and S100? were not significantly related to POD. Conclusion: HS can alleviate POD in geriatric patients and may inhibit the secretion of inflammatory factors by monocytes. äHypertonic saline for prevention of delirium in geriatric patients who(epmc).pdf DeepDyve Pubget Overpricing