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10.1186/s12935-017-0473-z http://scihub22266oqcxt.onion/10.1186/s12935-017-0473-z C5686942!5686942!29162985     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Cell+Int 2017 ; 17 (ä): ä Nephropedia Template TP {{tp|p=29162985|t=2017. CBFA2T2 is associated with a cancer stem cell state in renal cell carcinoma |pdf=|usr=}}{{29162985}} gab.com Text CBFA2T2 is associated with a cancer stem cell state in renal cell carcinoma JO: Cancer Cell Int http://www.kidney.de/pget.php?&tw=1&pmid=29162985 #FOAvip Background: Renal cell carcinoma (RCC) is the most common kidney cancer, accounting for approximately 80?90% of all primary kidney cancer. Treatment for patients with advanced RCC remains unsatisfactory. Rare cancer stem cells (CSCs) are proposed to be responsible for failure of current treatment. Methods: OncoLnc was used as a tool for interactively exploring survival correlations. Gene manipulation and expression analysis were carried out using siRNA, RT-PCR and Western blotting. Wound healing and invasion assays were used for phenotypical characterization. Aldefluor assay and FACS sorting Sphere culture were used to determine the ?stemness? of CSCs. Co-Immunoprecipitation (Co-IP) was used to examine the interaction between OCT4 and CBFA2T2. Student?s t-test and Chi square test was used to analyze statistical significance. Results: CBFA2T2 expression can significantly predict the survival of RCC patients. Knocking-down of CBFA2T2 can inhibit cell migration and invasion in RCC cells in vitro, and reduce ALDHhigh CSCs populations. CBFA2T2 expression is necessary for sphere-forming ability and cancer stem cells marker expression in RCC cell lines. Conclusions: Our data suggest that CBFA2T2 expression correlates with aggressive characteristics of RCC and CBFA2T2 is required for maintenance of ?stemness? through regulation of stem cells factors, thereby highlighting CBFA2T2 as a potential therapeutic target for RCC treatment. Electronic supplementary material: The online version of this article (10.1186/s12935-017-0473-z) contains supplementary material, which is available to authorized users. Twit Text FOAVip CBFA2T2 is associated with a cancer stem cell state in renal cell carcinoma ????Cancer Cell Int http://www.kidney.de/pget.php?&tw=1&pmid=29162985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29162985 #FOAvip English Wikipedia <ref>{{Cite pmid|29162985}}</ref> CBFA2T2 is associated with a cancer stem cell state in renal cell carcinoma #MMPMID29162985 Chen DC; Liang YD; Peng L; Wang YZ; Ai CZ; Zhu XX; Yan YW; Saeed Y; Yu B; Huang J; Gao Y; Liu J; Jiang YZ; Liu M; Chen D Cancer Cell Int 2017[]; 17 (ä): ä PMID29162985show ga Background: Renal cell carcinoma (RCC) is the most common kidney cancer, accounting for approximately 80?90% of all primary kidney cancer. Treatment for patients with advanced RCC remains unsatisfactory. Rare cancer stem cells (CSCs) are proposed to be responsible for failure of current treatment. Methods: OncoLnc was used as a tool for interactively exploring survival correlations. Gene manipulation and expression analysis were carried out using siRNA, RT-PCR and Western blotting. Wound healing and invasion assays were used for phenotypical characterization. Aldefluor assay and FACS sorting Sphere culture were used to determine the ?stemness? of CSCs. Co-Immunoprecipitation (Co-IP) was used to examine the interaction between OCT4 and CBFA2T2. Student?s t-test and Chi square test was used to analyze statistical significance. Results: CBFA2T2 expression can significantly predict the survival of RCC patients. Knocking-down of CBFA2T2 can inhibit cell migration and invasion in RCC cells in vitro, and reduce ALDHhigh CSCs populations. CBFA2T2 expression is necessary for sphere-forming ability and cancer stem cells marker expression in RCC cell lines. Conclusions: Our data suggest that CBFA2T2 expression correlates with aggressive characteristics of RCC and CBFA2T2 is required for maintenance of ?stemness? through regulation of stem cells factors, thereby highlighting CBFA2T2 as a potential therapeutic target for RCC treatment. Electronic supplementary material: The online version of this article (10.1186/s12935-017-0473-z) contains supplementary material, which is available to authorized users. äCBFA2T2 is associated with a cancer stem cell state in renal cell carc(epmc).pdf DeepDyve Pubget Overpricing