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10.1042/BSR20170125 http://scihub22266oqcxt.onion/10.1042/BSR20170125 C5686394!5686394 !28864784     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28864784 &cmd=llinks): Failed to open stream: HTTP request failed! 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SH003 reverses drug resistance by blocking signal transducer and activator of transcription 3 (STAT3) signaling in breast cancer cells |pdf=|usr=}}{{28864784 }} gab.com Text SH003 reverses drug resistance by blocking signal transducer and activator of transcription 3 (STAT3) signaling in breast cancer cells JO: Biosci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28864784 #FOAvip Overcoming drug resistance is an important task for investigators and clinician to achieve successful chemotherapy in cancer patients. Drug resistance is caused by various factors, including the overexpression of P-glycoprotein (P-gp, MDR1). The development of new, useful compounds that overcome drug resistance is urgent. SH003 is extracted from the mixture of three different herbs, and its anticancer effect has been revealed in different cancer cell types. In the present study, we investigated whether SH003 is able to reverse drug resistance using paclitaxel-resistant breast cancer cells (MCF-7/PAC). In our experiments, SH003 significantly decreased cell growth and colony formation in MCF-7/PAC cells and parental MCF-7 cells. This growth inhibition was related to the accumulation of cells in the sub-G(0)/G(1) apoptotic population and an increase in the number of apoptotic cells. SH003 reduced the mRNA expression of multidrug resistance 1 (MDR1) and multidrug resistance-associated proteins (MRPs) in MCF-7/PAC cells. SH003 also down-regulated the expression of P-gp. SH003 reversed drug efflux from MCF-7/PAC cells, resulting in rhodamine123 (Rho123) accumulation. Inhibition of drug resistance by SH003 is related to the suppression of the signal transducer and activator of transcription 3 (STAT3) signaling pathway. SH003 decreased STAT3 activation (p-STAT3) and its nuclear translocation and inhibited the secretion of VEGF and MMP-2, which are STAT3 target genes. An STAT3 inhibitor, JAK inhibitor I and an HIF-1? inhibitor decreased cell growth in MCF-7 and MCF-7/PAC cells. Taken together, these results demonstrate that SH003 can overcome drug resistance, and SH003 might be helpful for chemotherapy in cancer patients. Twit Text FOAVip SH003 reverses drug resistance by blocking signal transducer and activator of transcription 3 (STAT3) signaling in breast cancer cells ????Biosci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28864784 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28864784 #FOAvip English Wikipedia <ref>{{Cite pmid|28864784 }}</ref> SH003 reverses drug resistance by blocking signal transducer and activator of transcription 3 (STAT3) signaling in breast cancer cells #MMPMID28864784 Seo HS ; Ku JM ; Lee HJ ; Woo JK ; Cheon C ; Kim M ; Jang BH ; Shin YC ; Ko SG Biosci Rep 2017[Dec]; 37 (6 ): ä PMID28864784 show ga Overcoming drug resistance is an important task for investigators and clinician to achieve successful chemotherapy in cancer patients. Drug resistance is caused by various factors, including the overexpression of P-glycoprotein (P-gp, MDR1). The development of new, useful compounds that overcome drug resistance is urgent. SH003 is extracted from the mixture of three different herbs, and its anticancer effect has been revealed in different cancer cell types. In the present study, we investigated whether SH003 is able to reverse drug resistance using paclitaxel-resistant breast cancer cells (MCF-7/PAC). In our experiments, SH003 significantly decreased cell growth and colony formation in MCF-7/PAC cells and parental MCF-7 cells. This growth inhibition was related to the accumulation of cells in the sub-G(0)/G(1) apoptotic population and an increase in the number of apoptotic cells. SH003 reduced the mRNA expression of multidrug resistance 1 (MDR1) and multidrug resistance-associated proteins (MRPs) in MCF-7/PAC cells. SH003 also down-regulated the expression of P-gp. SH003 reversed drug efflux from MCF-7/PAC cells, resulting in rhodamine123 (Rho123) accumulation. Inhibition of drug resistance by SH003 is related to the suppression of the signal transducer and activator of transcription 3 (STAT3) signaling pathway. SH003 decreased STAT3 activation (p-STAT3) and its nuclear translocation and inhibited the secretion of VEGF and MMP-2, which are STAT3 target genes. An STAT3 inhibitor, JAK inhibitor I and an HIF-1? inhibitor decreased cell growth in MCF-7 and MCF-7/PAC cells. Taken together, these results demonstrate that SH003 can overcome drug resistance, and SH003 might be helpful for chemotherapy in cancer patients. |ATP Binding Cassette Transporter, Subfamily B/genetics/metabolism [MESH] |Angelica [MESH] |Antineoplastic Agents/*pharmacology/therapeutic use [MESH] |Apoptosis/drug effects [MESH] |Astragalus Plant [MESH] |Breast Neoplasms/*drug therapy [MESH] |Cell Proliferation/drug effects [MESH] |Drug Resistance, Neoplasm/*drug effects [MESH] |Female [MESH] |Humans [MESH] |MCF-7 Cells [MESH] |Paclitaxel/pharmacology [MESH] |Plant Extracts/*pharmacology/therapeutic use [MESH] |STAT3 Transcription Factor/genetics/*metabolism [MESH] |Trichosanthes [MESH]SH003 reverses drug resistance by blocking signal transducer and activ(epmc).pdf DeepDyve Pubget Overpricing