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10.1038/s41467-017-01646-6 http://scihub22266oqcxt.onion/10.1038/s41467-017-01646-6 C5686208!5686208 !29138395     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29138395 &cmd=llinks): Failed to open stream: HTTP request failed! 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Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys |pdf=|usr=}}{{29138395 }} gab.com Text Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29138395 #FOAvip Kidney injury initiates metabolic reprogramming in tubule cells that contributes to the development of chronic kidney disease (CKD). Exercise has been associated with beneficial effects in patients with CKD. Here we show that the induction of a myokine, irisin, improves kidney energy metabolism and prevents kidney damage. In response to kidney injury, mice with muscle-specific PGC-1? overexpression (mPGC-1?) exhibit reduced kidney damage and fibrosis. Metabolomics analysis reveals increased ATP production and improved energy metabolism in injured kidneys from mPGC-1? mice. We identify irisin as a serum factor that mediates these metabolic effects during progressive kidney injury by inhibiting TGF-? type 1 receptor. Irisin depletion from serum blunts the induction of oxygen consumption rate observed in tubule cells treated with mPGC-1? serum. In mice, recombinant irisin administration attenuates kidney damage and fibrosis and improves kidney functions. We suggest that myokine-mediated muscle-kidney crosstalk can suppress metabolic reprograming and fibrogenesis during kidney disease. Twit Text FOAVip Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29138395 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29138395 #FOAvip English Wikipedia <ref>{{Cite pmid|29138395 }}</ref> Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys #MMPMID29138395 Peng H ; Wang Q ; Lou T ; Qin J ; Jung S ; Shetty V ; Li F ; Wang Y ; Feng XH ; Mitch WE ; Graham BH ; Hu Z Nat Commun 2017[Nov]; 8 (1 ): 1493 PMID29138395 show ga Kidney injury initiates metabolic reprogramming in tubule cells that contributes to the development of chronic kidney disease (CKD). Exercise has been associated with beneficial effects in patients with CKD. Here we show that the induction of a myokine, irisin, improves kidney energy metabolism and prevents kidney damage. In response to kidney injury, mice with muscle-specific PGC-1? overexpression (mPGC-1?) exhibit reduced kidney damage and fibrosis. Metabolomics analysis reveals increased ATP production and improved energy metabolism in injured kidneys from mPGC-1? mice. We identify irisin as a serum factor that mediates these metabolic effects during progressive kidney injury by inhibiting TGF-? type 1 receptor. Irisin depletion from serum blunts the induction of oxygen consumption rate observed in tubule cells treated with mPGC-1? serum. In mice, recombinant irisin administration attenuates kidney damage and fibrosis and improves kidney functions. We suggest that myokine-mediated muscle-kidney crosstalk can suppress metabolic reprograming and fibrogenesis during kidney disease. |Adenosine Triphosphate/biosynthesis [MESH] |Animals [MESH] |Energy Metabolism [MESH] |Fibronectins/administration & dosage/*physiology [MESH] |Fibrosis [MESH] |Kidney Tubules/metabolism/pathology [MESH] |Kidney/pathology/*physiology [MESH] |Male [MESH] |Metabolomics [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Muscle, Skeletal/metabolism/*physiology [MESH] |Oxygen Consumption [MESH] |Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism [MESH] |Physical Conditioning, Animal [MESH] |Receptors, Transforming Growth Factor beta/antagonists & inhibitors/metabolism [MESH] |Recombinant Proteins/administration & dosage [MESH] |Renal Insufficiency, Chronic/*metabolism/pathology [MESH]Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogra(epmc).pdf DeepDyve Pubget Overpricing