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10.1038/s41598-017-15466-7 http://scihub22266oqcxt.onion/10.1038/s41598-017-15466-7 C5686106!5686106 !29138439     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29138439 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 15567 Nephropedia Template TP {{tp|p=29138439 |t=2017. ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments |pdf=|usr=}}{{29138439 }} gab.com Text ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29138439 #FOAvip Intracellular pathogenic microorganisms and toxins exploit host cell mechanisms to enter, exert their deleterious effects as well as hijack host nutrition for their development. A potential approach to treat multiple pathogen infections and that should not induce drug resistance is the use of small molecules that target host components. We identified the compound 1-adamantyl (5-bromo-2-methoxybenzyl) amine (ABMA) from a cell-based high throughput screening for its capacity to protect human cells and mice against ricin toxin without toxicity. This compound efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA provokes Rab7-positive late endosomal compartment accumulation in mammalian cells without affecting other organelles (early endosomes, lysosomes, the Golgi apparatus, the endoplasmic reticulum or the nucleus). As the mechanism of action of ABMA is restricted to host-endosomal compartments, it reduces cell infection by pathogens that depend on this pathway to invade cells. ABMA may represent a novel class of broad-spectrum compounds with therapeutic potential against diverse severe infectious diseases. Twit Text FOAVip ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29138439 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29138439 #FOAvip English Wikipedia <ref>{{Cite pmid|29138439 }}</ref> ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments #MMPMID29138439 Wu Y ; Pons V ; Goudet A ; Panigai L ; Fischer A ; Herweg JA ; Kali S ; Davey RA ; Laporte J ; Bouclier C ; Yousfi R ; Aubenque C ; Merer G ; Gobbo E ; Lopez R ; Gillet C ; Cojean S ; Popoff MR ; Clayette P ; Le Grand R ; Boulogne C ; Tordo N ; Lemichez E ; Loiseau PM ; Rudel T ; Sauvaire D ; Cintrat JC ; Gillet D ; Barbier J Sci Rep 2017[Nov]; 7 (1 ): 15567 PMID29138439 show ga Intracellular pathogenic microorganisms and toxins exploit host cell mechanisms to enter, exert their deleterious effects as well as hijack host nutrition for their development. A potential approach to treat multiple pathogen infections and that should not induce drug resistance is the use of small molecules that target host components. We identified the compound 1-adamantyl (5-bromo-2-methoxybenzyl) amine (ABMA) from a cell-based high throughput screening for its capacity to protect human cells and mice against ricin toxin without toxicity. This compound efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA provokes Rab7-positive late endosomal compartment accumulation in mammalian cells without affecting other organelles (early endosomes, lysosomes, the Golgi apparatus, the endoplasmic reticulum or the nucleus). As the mechanism of action of ABMA is restricted to host-endosomal compartments, it reduces cell infection by pathogens that depend on this pathway to invade cells. ABMA may represent a novel class of broad-spectrum compounds with therapeutic potential against diverse severe infectious diseases. |Adamantane/*analogs & derivatives/chemistry/pharmacology [MESH] |Animals [MESH] |Benzyl Compounds/chemistry/*pharmacology [MESH] |Benzylamines [MESH] |Cell Compartmentation/drug effects [MESH] |Endoplasmic Reticulum/drug effects [MESH] |Endosomes/*drug effects [MESH] |Golgi Apparatus/drug effects [MESH] |HeLa Cells [MESH] |Humans [MESH] |Lysosomes/drug effects [MESH] |Mice [MESH] |Ricin/*antagonists & inhibitors/drug effects/toxicity [MESH]ABMA, a small molecule that inhibits intracellular toxins and pathogen(epmc).pdf DeepDyve Pubget Overpricing