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10.1038/s41598-017-15558-4 http://scihub22266oqcxt.onion/10.1038/s41598-017-15558-4 C5686076!5686076 !29138462     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29138462 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens |pdf=|usr=}}{{29138462 }} gab.com Text The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29138462 #FOAvip Cystic fibrosis (CF) is characterized by recurrent airway infections with antibiotic-resistant bacteria and chronic inflammation. Chicken cathelicin-2 (CATH-2) has been shown to exhibit antimicrobial activity against antibiotic-resistant bacteria and to reduce inflammation. In addition, exogenous pulmonary surfactant has been suggested to enhance pulmonary drug delivery. It was hypothesized that CATH-2 when combined with an exogenous surfactant delivery vehicle, bovine lipid extract surfactant (BLES), would exhibit antimicrobial activity against CF-derived bacteria and downregulate inflammation. Twelve strains of CF-pathogens were exposed to BLES+CATH-2 in vitro and killing curves were obtained to determine bactericidal activity. Secondly, heat-killed bacteria were administered in vivo to elicit a pro-inflammatory response with either a co-administration or delayed administration of BLES+CATH-2 to assess the antimicrobial-independent, anti-inflammatory properties of BLES+CATH-2. CATH-2 alone exhibited potent antimicrobial activity against all clinical strains of antibiotic-resistant bacteria, while BLES+CATH-2 demonstrated a reduction, but significant antimicrobial activity against bacterial isolates. Furthermore, BLES+CATH-2 reduced inflammation in vivo when either co-administered with killed bacteria or after delayed administration. The use of a host-defense peptide combined with an exogenous surfactant compound, BLES+CATH-2, is shown to exhibit antimicrobial activity against antibiotic-resistant CF bacterial isolates and reduce inflammation. Twit Text FOAVip The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29138462 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29138462 #FOAvip English Wikipedia <ref>{{Cite pmid|29138462 }}</ref> The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens #MMPMID29138462 Banaschewski BJH ; Baer B ; Arsenault C ; Jazey T ; Veldhuizen EJA ; Delport J ; Gooyers T ; Lewis JF ; Haagsman HP ; Veldhuizen RAW ; Yamashita C Sci Rep 2017[Nov]; 7 (1 ): 15545 PMID29138462 show ga Cystic fibrosis (CF) is characterized by recurrent airway infections with antibiotic-resistant bacteria and chronic inflammation. Chicken cathelicin-2 (CATH-2) has been shown to exhibit antimicrobial activity against antibiotic-resistant bacteria and to reduce inflammation. In addition, exogenous pulmonary surfactant has been suggested to enhance pulmonary drug delivery. It was hypothesized that CATH-2 when combined with an exogenous surfactant delivery vehicle, bovine lipid extract surfactant (BLES), would exhibit antimicrobial activity against CF-derived bacteria and downregulate inflammation. Twelve strains of CF-pathogens were exposed to BLES+CATH-2 in vitro and killing curves were obtained to determine bactericidal activity. Secondly, heat-killed bacteria were administered in vivo to elicit a pro-inflammatory response with either a co-administration or delayed administration of BLES+CATH-2 to assess the antimicrobial-independent, anti-inflammatory properties of BLES+CATH-2. CATH-2 alone exhibited potent antimicrobial activity against all clinical strains of antibiotic-resistant bacteria, while BLES+CATH-2 demonstrated a reduction, but significant antimicrobial activity against bacterial isolates. Furthermore, BLES+CATH-2 reduced inflammation in vivo when either co-administered with killed bacteria or after delayed administration. The use of a host-defense peptide combined with an exogenous surfactant compound, BLES+CATH-2, is shown to exhibit antimicrobial activity against antibiotic-resistant CF bacterial isolates and reduce inflammation. |Achromobacter denitrificans/*drug effects [MESH] |Adult [MESH] |Anti-Bacterial Agents/pharmacology [MESH] |Antimicrobial Cationic Peptides/*pharmacology/therapeutic use [MESH] |Biological Products/*pharmacology [MESH] |Chronic Disease [MESH] |Cystic Fibrosis/microbiology/*therapy [MESH] |Drug Resistance, Bacterial [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Pseudomonas aeruginosa/*drug effects [MESH] |Pulmonary Surfactants/pharmacology [MESH] |Respiratory Tract Diseases/microbiology [MESH] |Staphylococcus aureus/*drug effects [MESH]The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicid(epmc).pdf DeepDyve Pubget Overpricing