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10.18632/oncotarget.19361 http://scihub22266oqcxt.onion/10.18632/oncotarget.19361 C5685771!5685771!29163850     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (52): 90521-31 Nephropedia Template TP {{tp|p=29163850|t=2017. Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: challenges and opportunities |pdf=|usr=}}{{29163850}} gab.com Text Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: challenges and opportunities JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29163850 #FOAvip Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have been shown to have unprecedented efficacy in B cell malignancies, most notably in B cell acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate using anti-CD19 CAR-T cells. However, CAR T-cell therapy for solid tumors currently is faced with numerous challenges such as physical barriers, the immunosuppressive tumor microenvironment and the specificity and safety. The clinical results in solid tumors have been much less encouraging, with multiple cases of toxicity and a lack of therapeutic response. In this review, we will discuss the current stats and challenges of CAR-T cell therapy for solid tumors, and propose possibl e solutions and future perspectives. Twit Text FOAVip Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: challenges and opportunities ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29163850 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29163850 #FOAvip English Wikipedia <ref>{{Cite pmid|29163850}}</ref> Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: challenges and opportunities #MMPMID29163850 Xia AL; Wang XC; Lu YJ; Lu XJ; Sun B Oncotarget 2017[Oct]; 8 (52): 90521-31 PMID29163850show ga Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have been shown to have unprecedented efficacy in B cell malignancies, most notably in B cell acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate using anti-CD19 CAR-T cells. However, CAR T-cell therapy for solid tumors currently is faced with numerous challenges such as physical barriers, the immunosuppressive tumor microenvironment and the specificity and safety. The clinical results in solid tumors have been much less encouraging, with multiple cases of toxicity and a lack of therapeutic response. In this review, we will discuss the current stats and challenges of CAR-T cell therapy for solid tumors, and propose possibl e solutions and future perspectives. äChimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: cha(epmc).pdf DeepDyve Pubget Overpricing