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10.18632/oncotarget.19002 http://scihub22266oqcxt.onion/10.18632/oncotarget.19002 C5685686!5685686!29163765     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (52): 89486-99 Nephropedia Template TP {{tp|p=29163765|t=2017. B cells regulate thymic CD8+T cell differentiation in lupus-prone mice |pdf=|usr=}}{{29163765}} gab.com Text B cells regulate thymic CD8+T cell differentiation in lupus-prone mice JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29163765 #FOAvip Previous studies have shown that under normal physiological conditions thymic B cells play a critical function in T cell negative selection. We tested the effect of thymic B cells on thymic T-cell differentiation in autoimmune diseases including systemic lupus erythematosus (SLE). We found that thymic B cells and CD8- CD4+ and CD4-CD8+T cells increased, whereas CD4+CD8+T cells decreased in lupus-prone mice. Once B cells were reduced, the change was reversed. Furthermore, we found that B cells blocked thymic immature single positive (ISP) CD4-CD8+CD3lo/-ROR?t- T cells progression into CD4+CD8+T cells. Interestingly, we found a novel population of thymic immature T cells (CD4-CD8+CD3loROR?t+) that were induced into mature CD4-CD8+CD3+ROR?t+T cells by B cells in lupus-prone mice. Importantly, we found that IgG, produced by thymic B cells, played a critical role in the differentiation of thymic CD8+ISP and mature ROR?t+CD8+ T cells in lupus-prone mice. In conclusion, B cells blocked the differentiation from thymic CD8+ISP and induced the differentiation of a novel immature CD4-CD8+CD3loROR?t+T cells into mature ROR?t+CD8+ T cells by secreting IgG antibody in lupus-prone mice. Twit Text FOAVip B cells regulate thymic CD8+T cell differentiation in lupus-prone mice ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29163765 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29163765 #FOAvip English Wikipedia <ref>{{Cite pmid|29163765}}</ref> B cells regulate thymic CD8+T cell differentiation in lupus-prone mice #MMPMID29163765 Xing C; Zhu G; Xiao H; Fang Y; Liu X; Han G; Chen G; Hou C; Shen B; Li Y; Ma N; Wang R Oncotarget 2017[Oct]; 8 (52): 89486-99 PMID29163765show ga Previous studies have shown that under normal physiological conditions thymic B cells play a critical function in T cell negative selection. We tested the effect of thymic B cells on thymic T-cell differentiation in autoimmune diseases including systemic lupus erythematosus (SLE). We found that thymic B cells and CD8- CD4+ and CD4-CD8+T cells increased, whereas CD4+CD8+T cells decreased in lupus-prone mice. Once B cells were reduced, the change was reversed. Furthermore, we found that B cells blocked thymic immature single positive (ISP) CD4-CD8+CD3lo/-ROR?t- T cells progression into CD4+CD8+T cells. Interestingly, we found a novel population of thymic immature T cells (CD4-CD8+CD3loROR?t+) that were induced into mature CD4-CD8+CD3+ROR?t+T cells by B cells in lupus-prone mice. Importantly, we found that IgG, produced by thymic B cells, played a critical role in the differentiation of thymic CD8+ISP and mature ROR?t+CD8+ T cells in lupus-prone mice. In conclusion, B cells blocked the differentiation from thymic CD8+ISP and induced the differentiation of a novel immature CD4-CD8+CD3loROR?t+T cells into mature ROR?t+CD8+ T cells by secreting IgG antibody in lupus-prone mice. äB cells regulate thymic CD8+T cell differentiation in lupus-prone mice(epmc).pdf DeepDyve Pubget Overpricing