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10.18632/oncotarget.18324 http://scihub22266oqcxt.onion/10.18632/oncotarget.18324 C5685685!5685685!29163764     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (52): 89475-85 Nephropedia Template TP {{tp|p=29163764|t=2017. Inhibition of autoimmune Th17 cell responses by pain killer ketamine |pdf=|usr=}}{{29163764}} gab.com Text Inhibition of autoimmune Th17 cell responses by pain killer ketamine JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29163764 #FOAvip Ketamine is widely used in animals and humans as a systemic anesthetic. Although several immune-modulatory functions of ketamine have been reported, the effects of ketamine on the differentiation of Th17 cell are unknown. We found that ketamine significantly diminished the frequency of IL-17-producers among CD4+ T cells stimulated under Th17-skewing conditions. Mechanistic studies showed that ketamine had little effect on the production of Th17-inducing cytokines by dendritic cells and the proliferation of T cells in response to anti-CD3; however it significantly hampered IL-21 expression as well as STAT3 phosphorylation in T cells upon IL-6 stimulation. Moreover, MOG-reactive CD4+ T cells expanded in the presence of ketamine produced reduced amounts of Th17 cytokines, leading to diminished EAE severity when transferred into TCR?-deficient mice in comparison to those treated with vehicle. These findings demonstrate that ketamine suppresses autoimmune Th17 cell responses by inhibiting the differentiation as well as the reactivation of Th17 cells. Twit Text FOAVip Inhibition of autoimmune Th17 cell responses by pain killer ketamine ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29163764 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29163764 #FOAvip English Wikipedia <ref>{{Cite pmid|29163764}}</ref> Inhibition of autoimmune Th17 cell responses by pain killer ketamine #MMPMID29163764 Lee JE; Lee JM; Park YJ; Kim BS; Jeon YT; Chung Y Oncotarget 2017[Oct]; 8 (52): 89475-85 PMID29163764show ga Ketamine is widely used in animals and humans as a systemic anesthetic. Although several immune-modulatory functions of ketamine have been reported, the effects of ketamine on the differentiation of Th17 cell are unknown. We found that ketamine significantly diminished the frequency of IL-17-producers among CD4+ T cells stimulated under Th17-skewing conditions. Mechanistic studies showed that ketamine had little effect on the production of Th17-inducing cytokines by dendritic cells and the proliferation of T cells in response to anti-CD3; however it significantly hampered IL-21 expression as well as STAT3 phosphorylation in T cells upon IL-6 stimulation. Moreover, MOG-reactive CD4+ T cells expanded in the presence of ketamine produced reduced amounts of Th17 cytokines, leading to diminished EAE severity when transferred into TCR?-deficient mice in comparison to those treated with vehicle. These findings demonstrate that ketamine suppresses autoimmune Th17 cell responses by inhibiting the differentiation as well as the reactivation of Th17 cells. äInhibition of autoimmune Th17 cell responses by pain killer ketamine (epmc).pdf DeepDyve Pubget Overpricing