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10.1371/journal.pone.0187532 http://scihub22266oqcxt.onion/10.1371/journal.pone.0187532 C5685615!5685615 !29135982     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29135982 &cmd=llinks): Failed to open stream: HTTP request failed! 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STING expression and response to treatment with STING ligands in premalignant and malignant disease |pdf=|usr=}}{{29135982 }} gab.com Text STING expression and response to treatment with STING ligands in premalignant and malignant disease JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29135982 #FOAvip Human papilloma virus positive (HPV+) tumors represent a large proportion of anal, vulvar, vaginal, cervical and head and neck squamous carcinomas (HNSCC) and late stage invasive disease is thought to originate from a premalignant state. Cyclic dinucleotides that activate STimulator of INterferon Genes (STING) have been shown to cause rapid regression of a range of advanced tumors. We aimed to investigate STING ligands as a novel treatment for papilloma. We tested therapies in a spontaneous mouse model of papilloma of the face and anogenital region that histologically resembles human HPV-associated papilloma. We demonstrate that STING ligands cause rapid regression of papilloma, associated with T cell infiltration, and are significantly more effective than Imiquimod, a current immunotherapy for papilloma. In humans, we show that STING is expressed in the basal layer of normal skin and lost during keratinocyte differentiation. We found STING was expressed in all HPV-associated cervical and anal dysplasia and was strongly expressed in the cancer cells of HPV+ HNSCC but not in HPV-unrelated HNSCC. We found no strong association between STING expression and progressive disease in non-HPV oral dysplasia and oral pre-malignancies that are not HPV-related. These data demonstrate that STING is expressed in basal cells of the skin and is retained in HPV+ pre-malignancies and advanced cancers, but not in HPV-unrelated HNSCC. However, using a murine HNSCC model that does not express STING, we demonstrate that STING ligands are an effective therapy regardless of expression of STING by the cancer cells. Twit Text FOAVip STING expression and response to treatment with STING ligands in premalignant and malignant disease ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29135982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29135982 #FOAvip English Wikipedia <ref>{{Cite pmid|29135982 }}</ref> STING expression and response to treatment with STING ligands in premalignant and malignant disease #MMPMID29135982 Baird JR ; Feng Z ; Xiao HD ; Friedman D ; Cottam B ; Fox BA ; Kramer G ; Leidner RS ; Bell RB ; Young KH ; Crittenden MR ; Gough MJ PLoS One 2017[]; 12 (11 ): e0187532 PMID29135982 show ga Human papilloma virus positive (HPV+) tumors represent a large proportion of anal, vulvar, vaginal, cervical and head and neck squamous carcinomas (HNSCC) and late stage invasive disease is thought to originate from a premalignant state. Cyclic dinucleotides that activate STimulator of INterferon Genes (STING) have been shown to cause rapid regression of a range of advanced tumors. We aimed to investigate STING ligands as a novel treatment for papilloma. We tested therapies in a spontaneous mouse model of papilloma of the face and anogenital region that histologically resembles human HPV-associated papilloma. We demonstrate that STING ligands cause rapid regression of papilloma, associated with T cell infiltration, and are significantly more effective than Imiquimod, a current immunotherapy for papilloma. In humans, we show that STING is expressed in the basal layer of normal skin and lost during keratinocyte differentiation. We found STING was expressed in all HPV-associated cervical and anal dysplasia and was strongly expressed in the cancer cells of HPV+ HNSCC but not in HPV-unrelated HNSCC. We found no strong association between STING expression and progressive disease in non-HPV oral dysplasia and oral pre-malignancies that are not HPV-related. These data demonstrate that STING is expressed in basal cells of the skin and is retained in HPV+ pre-malignancies and advanced cancers, but not in HPV-unrelated HNSCC. However, using a murine HNSCC model that does not express STING, we demonstrate that STING ligands are an effective therapy regardless of expression of STING by the cancer cells. |Alphapapillomavirus/*isolation & purification [MESH] |Animals [MESH] |Female [MESH] |Humans [MESH] |Ligands [MESH] |Male [MESH] |Membrane Proteins/*metabolism [MESH] |Mice [MESH] |Neoplasms/drug therapy/metabolism/*virology [MESH]STING expression and response to treatment with STING ligands in prema(epmc).pdf DeepDyve Pubget Overpricing