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http://scihub22266oqcxt.onion/ C5685547!5685547!29147673     free     free     free       Cancer+Cell+Microenviron 2017 ; 4 (2): ä Nephropedia Template TP {{tp|p=29147673|t=2017. The regulation of snail: on the ubiquitin edge |pdf=|usr=}}{{29147673}} gab.com Text The regulation of snail: on the ubiquitin edge JO: Cancer Cell Microenviron http://www.kidney.de/pget.php?&tw=1&pmid=29147673 #FOAvip Metastasis accounts for a majority of cancer death. One key feature during metastasis is epithelial-mesenchymal transition (EMT), which is regulated by transcription factors such as Snail and Twist. In non-malignant cells, Snail has a short half-life and is degraded via ubiquitination, but its stability is increased in cancer cell. However, the mechanism by which Snail escapes ubiquitination and degradation remains unknown. Recently, we found that Dub3 is a deubiquinase of Snail. Most importantly, we determined that Dub3 responded to extracellular signals such as IL-6, and that the resultant signaling prevented Snail degradation, and promoted cancer growth, invasion, and migration. In this highlight, we present a concise picture of how the transcription factor Snail is regulated by ubiquitination in cancer cells, the role of Dub3 in this process, and its potential use as a treatment target. Twit Text FOAVip The regulation of snail: on the ubiquitin edge ????Cancer Cell Microenviron http://www.kidney.de/pget.php?&tw=1&pmid=29147673 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29147673 #FOAvip English Wikipedia <ref>{{Cite pmid|29147673}}</ref> The regulation of snail: on the ubiquitin edge #MMPMID29147673 Yu Q; Zhou BP; Wu Y Cancer Cell Microenviron 2017[]; 4 (2): ä PMID29147673show ga Metastasis accounts for a majority of cancer death. One key feature during metastasis is epithelial-mesenchymal transition (EMT), which is regulated by transcription factors such as Snail and Twist. In non-malignant cells, Snail has a short half-life and is degraded via ubiquitination, but its stability is increased in cancer cell. However, the mechanism by which Snail escapes ubiquitination and degradation remains unknown. Recently, we found that Dub3 is a deubiquinase of Snail. Most importantly, we determined that Dub3 responded to extracellular signals such as IL-6, and that the resultant signaling prevented Snail degradation, and promoted cancer growth, invasion, and migration. In this highlight, we present a concise picture of how the transcription factor Snail is regulated by ubiquitination in cancer cells, the role of Dub3 in this process, and its potential use as a treatment target. äThe regulation of snail: on the ubiquitin edge (epmc).pdf DeepDyve Pubget Overpricing