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10.7554/eLife.31268 http://scihub22266oqcxt.onion/10.7554/eLife.31268 C5685485!5685485!29027899     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=29027899|t=2017. Metformin extends C elegans lifespan through lysosomal pathway |pdf=|usr=}}{{29027899}} gab.com Text Metformin extends C elegans lifespan through lysosomal pathway JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=29027899 #FOAvip Metformin, a widely used first-line drug for treatment of type 2 diabetes (T2D), has been shown to extend lifespan and delay the onset of age-related diseases. However, its primary locus of action remains unclear. Using a pure in vitro reconstitution system, we demonstrate that metformin acts through the v-ATPase-Ragulator lysosomal pathway to coordinate mTORC1 and AMPK, two hubs governing metabolic programs. We further show in Caenorhabditis elegans that both v-ATPase-mediated TORC1 inhibition and v-ATPase-AXIN/LKB1-mediated AMPK activation contribute to the lifespan extension effect of metformin. Elucidating the molecular mechanism of metformin regulated healthspan extension will boost its therapeutic application in the treatment of human aging and age-related diseases. Twit Text FOAVip Metformin extends C elegans lifespan through lysosomal pathway ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=29027899 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29027899 #FOAvip English Wikipedia <ref>{{Cite pmid|29027899}}</ref> Metformin extends C elegans lifespan through lysosomal pathway #MMPMID29027899 Chen J; Ou Y; Li Y; Hu S; Shao LW; Liu Y eLife 2017[]; 6 (ä): ä PMID29027899show ga Metformin, a widely used first-line drug for treatment of type 2 diabetes (T2D), has been shown to extend lifespan and delay the onset of age-related diseases. However, its primary locus of action remains unclear. Using a pure in vitro reconstitution system, we demonstrate that metformin acts through the v-ATPase-Ragulator lysosomal pathway to coordinate mTORC1 and AMPK, two hubs governing metabolic programs. We further show in Caenorhabditis elegans that both v-ATPase-mediated TORC1 inhibition and v-ATPase-AXIN/LKB1-mediated AMPK activation contribute to the lifespan extension effect of metformin. Elucidating the molecular mechanism of metformin regulated healthspan extension will boost its therapeutic application in the treatment of human aging and age-related diseases. äMetformin extends C elegans lifespan through lysosomal pathway (epmc).pdf DeepDyve Pubget Overpricing