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10.4062/biomolther.2017.173 http://scihub22266oqcxt.onion/10.4062/biomolther.2017.173 C5685434!5685434!29081092     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29081092&cmd=llinks): Failed to open stream: HTTP request failed! 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Galangin Suppresses Pro-Inflammatory Gene Expression in Polyinosinic-Polycytidylic Acid-Stimulated Microglial Cells |pdf=|usr=}}{{29081092}} gab.com Text Galangin Suppresses Pro-Inflammatory Gene Expression in Polyinosinic-Polycytidylic Acid-Stimulated Microglial Cells JO: Biomol Ther (Seoul) http://www.kidney.de/pget.php?&tw=1&pmid=29081092 #FOAvip Galangin (3,5,7-trihydroxyflavone) is a polyphenolic compound abundant in honey and medicinal herbs, such as Alpinia officinarum. In this study, we investigated the anti-inflammatory effects of galangin under in vitro and in vivo neuroinflammatory conditions caused by polyinosinic-polycytidylic acid (poly(I:C)), a viral mimic dsRNA analog. Galangin suppressed the production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in poly(I:C)-stimulated BV2 microglia. On the other hand, galangin enhanced anti-inflammatory interleukin (IL)-10 production. Galangin also suppressed the expression of pro-inflammatory markers in poly(I:C)-injected mouse brains. Further mechanistic studies showed that galangin inhibited poly(I:C)-induced nuclear factor (NF)-?B activity and phosphorylation of Akt without affecting MAP kinases. Interestingly, galangin increased the expression and transcriptional activity of peroxisome proliferator-activated receptor (PPAR)-?, known to play an anti-inflammatory role. To investigate whether PPAR-? is involved in the anti-inflammatory function of galangin, BV2 cells were pre-treated with PPAR-? antagonist before treatment of galangin. We found that PPAR-? antagonist significantly blocked galangin-mediated upregulation of IL-10 and attenuated the inhibition of tumor necrosis factor (TNF)-? and IL-6 in poly(I:C)-stimulated microglia. In conclusion, our data suggest that PI3K/Akt, NF-?B, and PPAR-? play a pivotal role in mediating the anti-inflammatory effects of galangin in poly(I:C)-stimulated microglia. Twit Text FOAVip Galangin Suppresses Pro-Inflammatory Gene Expression in Polyinosinic-Polycytidylic Acid-Stimulated Microglial Cells ????Biomol Ther (Seoul) http://www.kidney.de/pget.php?&tw=1&pmid=29081092 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29081092 #FOAvip English Wikipedia <ref>{{Cite pmid|29081092}}</ref> Galangin Suppresses Pro-Inflammatory Gene Expression in Polyinosinic-Polycytidylic Acid-Stimulated Microglial Cells #MMPMID29081092 Choi MJ; Park JS; Park JE; Kim HS; Kim HS Biomol Ther (Seoul) 2017[Nov]; 25 (6): 641-7 PMID29081092show ga Galangin (3,5,7-trihydroxyflavone) is a polyphenolic compound abundant in honey and medicinal herbs, such as Alpinia officinarum. In this study, we investigated the anti-inflammatory effects of galangin under in vitro and in vivo neuroinflammatory conditions caused by polyinosinic-polycytidylic acid (poly(I:C)), a viral mimic dsRNA analog. Galangin suppressed the production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in poly(I:C)-stimulated BV2 microglia. On the other hand, galangin enhanced anti-inflammatory interleukin (IL)-10 production. Galangin also suppressed the expression of pro-inflammatory markers in poly(I:C)-injected mouse brains. Further mechanistic studies showed that galangin inhibited poly(I:C)-induced nuclear factor (NF)-?B activity and phosphorylation of Akt without affecting MAP kinases. Interestingly, galangin increased the expression and transcriptional activity of peroxisome proliferator-activated receptor (PPAR)-?, known to play an anti-inflammatory role. To investigate whether PPAR-? is involved in the anti-inflammatory function of galangin, BV2 cells were pre-treated with PPAR-? antagonist before treatment of galangin. We found that PPAR-? antagonist significantly blocked galangin-mediated upregulation of IL-10 and attenuated the inhibition of tumor necrosis factor (TNF)-? and IL-6 in poly(I:C)-stimulated microglia. In conclusion, our data suggest that PI3K/Akt, NF-?B, and PPAR-? play a pivotal role in mediating the anti-inflammatory effects of galangin in poly(I:C)-stimulated microglia. äGalangin Suppresses Pro-Inflammatory Gene Expression in Polyinosinic-P(epmc).pdf DeepDyve Pubget Overpricing